Magnetic source imaging localizes epileptogenic zone in children with tuberous sclerosis complex

J. Y. Wu*, W. W. Sutherling, S. Koh, N. Salamon, R. Jonas, S. Yudovin, R. Sankar, W. D. Shields, G. W. Mathern

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

The authors assessed whether magnetoencephalography/magnetic source imaging (MEG/MSI) identified epileptogenic zones in patients with tuberous sclerosis complex (TSC). In six TSC children with focal seizures, ictal video-EEG predicted the region of resection with 56% sensitivity, 80% specificity, and 77% accuracy (p = 0.02), whereas interictal MEG/MSI fared better (100%, 94%, and 95%, respectively; p < 0.0001). Interictal MEG/MSI seems to identify epileptogenic zones more accurately in children with TSC and focal intractable epilepsy.

Original languageEnglish (US)
Pages (from-to)1270-1272
Number of pages3
JournalNeurology
Volume66
Issue number8
DOIs
StatePublished - Apr 2006
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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