Magnetic source imaging localizes epileptogenic zone in children with tuberous sclerosis complex

J. Y. Wu; W. W. Sutherling; S. Koh; N. Salamon; R. Jonas; S. Yudovin; R. Sankar; W. D. Shields; G. W. Mathern

doi:10.1212/01.wnl.0000208412.59491.9b

Magnetic source imaging localizes epileptogenic zone in children with tuberous sclerosis complex

J. Y. Wu^*, W. W. Sutherling, S. Koh, N. Salamon, R. Jonas, S. Yudovin, R. Sankar, W. D. Shields, G. W. Mathern

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

The authors assessed whether magnetoencephalography/magnetic source imaging (MEG/MSI) identified epileptogenic zones in patients with tuberous sclerosis complex (TSC). In six TSC children with focal seizures, ictal video-EEG predicted the region of resection with 56% sensitivity, 80% specificity, and 77% accuracy (p = 0.02), whereas interictal MEG/MSI fared better (100%, 94%, and 95%, respectively; p < 0.0001). Interictal MEG/MSI seems to identify epileptogenic zones more accurately in children with TSC and focal intractable epilepsy.

Original language	English (US)
Pages (from-to)	1270-1272
Number of pages	3
Journal	Neurology
Volume	66
Issue number	8
DOIs	https://doi.org/10.1212/01.wnl.0000208412.59491.9b
State	Published - Apr 2006
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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title = "Magnetic source imaging localizes epileptogenic zone in children with tuberous sclerosis complex",

abstract = "The authors assessed whether magnetoencephalography/magnetic source imaging (MEG/MSI) identified epileptogenic zones in patients with tuberous sclerosis complex (TSC). In six TSC children with focal seizures, ictal video-EEG predicted the region of resection with 56% sensitivity, 80% specificity, and 77% accuracy (p = 0.02), whereas interictal MEG/MSI fared better (100%, 94%, and 95%, respectively; p < 0.0001). Interictal MEG/MSI seems to identify epileptogenic zones more accurately in children with TSC and focal intractable epilepsy.",

author = "Wu, {J. Y.} and Sutherling, {W. W.} and S. Koh and N. Salamon and R. Jonas and S. Yudovin and R. Sankar and Shields, {W. D.} and Mathern, {G. W.}",

year = "2006",

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doi = "10.1212/01.wnl.0000208412.59491.9b",

language = "English (US)",

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AU - Wu, J. Y.

AU - Sutherling, W. W.

AU - Koh, S.

AU - Salamon, N.

AU - Jonas, R.

AU - Yudovin, S.

AU - Sankar, R.

AU - Shields, W. D.

AU - Mathern, G. W.

PY - 2006/4

Y1 - 2006/4

N2 - The authors assessed whether magnetoencephalography/magnetic source imaging (MEG/MSI) identified epileptogenic zones in patients with tuberous sclerosis complex (TSC). In six TSC children with focal seizures, ictal video-EEG predicted the region of resection with 56% sensitivity, 80% specificity, and 77% accuracy (p = 0.02), whereas interictal MEG/MSI fared better (100%, 94%, and 95%, respectively; p < 0.0001). Interictal MEG/MSI seems to identify epileptogenic zones more accurately in children with TSC and focal intractable epilepsy.

AB - The authors assessed whether magnetoencephalography/magnetic source imaging (MEG/MSI) identified epileptogenic zones in patients with tuberous sclerosis complex (TSC). In six TSC children with focal seizures, ictal video-EEG predicted the region of resection with 56% sensitivity, 80% specificity, and 77% accuracy (p = 0.02), whereas interictal MEG/MSI fared better (100%, 94%, and 95%, respectively; p < 0.0001). Interictal MEG/MSI seems to identify epileptogenic zones more accurately in children with TSC and focal intractable epilepsy.

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