Magneto-thermally responsive hydrogels for bladder cancer treatment: Therapeutic efficacy and in vivo biodistribution

Manish K. Jaiswal, Lina Pradhan, Shaleen Vasavada, Mrinmoy De, H. D. Sarma, Anand Prakash, D. Bahadur*, Vinayak P. Dravid

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Bladder cancer is one of the deadliest forms of cancer in modern medicine which despite recent progress has remained incurable and challenging for researchers. There is unmet need to address this endemic as the number of patients are growing by about 10,000 every year world-wide. Here, we report a minimally invasive magnetic chemotherapy method to address this problem where polyethylene glycol (PEG) functionalized Fe3O4 magnetic nanostructures (MNS) are homogeneously embedded in thermally responsive poly(N-isopropylacrylamide, NIPAAm) hydrogels (HG). The system (HG-MNS) loaded with anti-cancer drug doxorubicin (DOX) incubated with cancer cell lines subjected to external radiofrequency (RF) field can remotely stimulate the release of drug smartly at the site. The in vitro efficacy investigated on bladder cancer (T-24) cell lines showed the potential of the system in dealing with the disease successfully. Further, the materials preferential accumulation via systemic delivery was studied using swiss mice model. Vital tissue organs like liver, lung and heart were analysed by magnetic resonance imaging (MRI). A detail accounts of the materials optimization, cytotoxicity and anti-proliferation activity tests with apoptosis analysis by flow cytometry after RF exposure (250kHz) to the cells and in vivo biodistribution data are discussed in the paper.

Original languageEnglish (US)
Pages (from-to)625-633
Number of pages9
JournalColloids and Surfaces B: Biointerfaces
Volume136
DOIs
StatePublished - Dec 1 2015

Keywords

  • Bladder cancer
  • Magnetic chemotherapy
  • Magnetic resonance imaging
  • Magneto-thermally responsive hydrogel
  • PEG functionalized FeO

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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