Major Comorbidities of Atopic Dermatitis: Beyond Allergic Disorders

Amy Paller*, Jennifer C. Jaworski, Eric L. Simpson, Mark Boguniewicz, John J. Russell, Julie K. Block, Susan Tofte, Jeffrey D. Dunn, Steven R. Feldman, Adele R. Clark, Gene Schwartz, Lawrence F. Eichenfield

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

129 Scopus citations


The consequences of atopic dermatitis reach beyond the skin and past childhood. Patients with atopic dermatitis are at risk of developing allergic comorbidities, but less is known about the associations between atopic dermatitis and non-allergic conditions. Understanding these non-allergic comorbidities has the potential to improve patient outcomes and to help mitigate the cost and burdens associated with these conditions. Atopic dermatitis is associated with cutaneous bacterial infections, more severe forms/courses of cutaneous viral infections, and extra-cutaneous infections. Atopic dermatitis is also associated with several mental health comorbidities particularly attention-deficit hyperactivity disorder, anxiety, and depression. Data are largely inconsistent for specific cancers, but atopic dermatitis appears to protect against malignancy overall; severe long-term atopic dermatitis is associated with adult lymphomas. Atopic dermatitis may also be associated with obesity, cardiovascular disease, and autoimmune disease, particularly alopecia areata and gastrointestinal immune-mediated disorders. Although the causative mechanisms underlying these associations are poorly understood, treating physicians should be aware of associations in seeking to alleviate the burden for patients with atopic dermatitis.

Original languageEnglish (US)
Pages (from-to)821-838
Number of pages18
JournalAmerican Journal of Clinical Dermatology
Issue number6
StatePublished - Dec 1 2018

ASJC Scopus subject areas

  • Dermatology


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