Major histocompatibility complex genes in a Mexican family with deficiency of the second component of the complement system

Héctor Melín-Aldana; Pedro Reyes; Gilberto Vargas-Alarcón; Jesús K. Yamamoto-Furusho; Julio Granados

Major histocompatibility complex genes in a Mexican family with deficiency of the second component of the complement system

Héctor Melín-Aldana, Pedro Reyes, Gilberto Vargas-Alarcón, Jesús K. Yamamoto-Furusho, Julio Granados^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

Hereditary deficiency of the second component of the complement system is an uncommon condition that has been reported so far mostly in Caucasians. We describe a Mexican patient with undetectable C2 levels and absence of complement hemolytic activity. Major histocompatibility complex (MHC) genes in his family showed that the proband had the MHC haplotypes HLA-A25, B18, DR2, DQ1, SQ042/HLA-A24, B18, DR2, DQ1, SQ042. A strong genetic linkage of the deficiency of the second component of the complement gene and the HLA antigens A25, B18, and DR2, is well established in Caucasian populations. This suggests that the probable origin of the deficiency in our patient was admixture with Caucasian ancestors.

Original language	English (US)
Pages (from-to)	307-309
Number of pages	3
Journal	Revista de Investigacion Clinica
Volume	48
Issue number	4
State	Published - Jul 1 1996

Keywords

C2-deficiency
Complement genes
Mayor histocompatibility complex
Mexican population

ASJC Scopus subject areas

Medicine(all)

Cite this

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title = "Major histocompatibility complex genes in a Mexican family with deficiency of the second component of the complement system",

abstract = "Hereditary deficiency of the second component of the complement system is an uncommon condition that has been reported so far mostly in Caucasians. We describe a Mexican patient with undetectable C2 levels and absence of complement hemolytic activity. Major histocompatibility complex (MHC) genes in his family showed that the proband had the MHC haplotypes HLA-A25, B18, DR2, DQ1, SQ042/HLA-A24, B18, DR2, DQ1, SQ042. A strong genetic linkage of the deficiency of the second component of the complement gene and the HLA antigens A25, B18, and DR2, is well established in Caucasian populations. This suggests that the probable origin of the deficiency in our patient was admixture with Caucasian ancestors.",

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T1 - Major histocompatibility complex genes in a Mexican family with deficiency of the second component of the complement system

AU - Melín-Aldana, Héctor

AU - Reyes, Pedro

AU - Vargas-Alarcón, Gilberto

AU - Yamamoto-Furusho, Jesús K.

AU - Granados, Julio

PY - 1996/7/1

Y1 - 1996/7/1

N2 - Hereditary deficiency of the second component of the complement system is an uncommon condition that has been reported so far mostly in Caucasians. We describe a Mexican patient with undetectable C2 levels and absence of complement hemolytic activity. Major histocompatibility complex (MHC) genes in his family showed that the proband had the MHC haplotypes HLA-A25, B18, DR2, DQ1, SQ042/HLA-A24, B18, DR2, DQ1, SQ042. A strong genetic linkage of the deficiency of the second component of the complement gene and the HLA antigens A25, B18, and DR2, is well established in Caucasian populations. This suggests that the probable origin of the deficiency in our patient was admixture with Caucasian ancestors.

AB - Hereditary deficiency of the second component of the complement system is an uncommon condition that has been reported so far mostly in Caucasians. We describe a Mexican patient with undetectable C2 levels and absence of complement hemolytic activity. Major histocompatibility complex (MHC) genes in his family showed that the proband had the MHC haplotypes HLA-A25, B18, DR2, DQ1, SQ042/HLA-A24, B18, DR2, DQ1, SQ042. A strong genetic linkage of the deficiency of the second component of the complement gene and the HLA antigens A25, B18, and DR2, is well established in Caucasian populations. This suggests that the probable origin of the deficiency in our patient was admixture with Caucasian ancestors.

KW - C2-deficiency

KW - Complement genes

KW - Mayor histocompatibility complex

KW - Mexican population

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VL - 48

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JO - Revista de Investigacion Clinica

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ER -

Major histocompatibility complex genes in a Mexican family with deficiency of the second component of the complement system

Abstract

Keywords

ASJC Scopus subject areas

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