TY - JOUR
T1 - Major histocompatibility complex genes in a Mexican family with deficiency of the second component of the complement system
AU - Melín-Aldana, Héctor
AU - Reyes, Pedro
AU - Vargas-Alarcón, Gilberto
AU - Yamamoto-Furusho, Jesús K.
AU - Granados, Julio
PY - 1996/7/1
Y1 - 1996/7/1
N2 - Hereditary deficiency of the second component of the complement system is an uncommon condition that has been reported so far mostly in Caucasians. We describe a Mexican patient with undetectable C2 levels and absence of complement hemolytic activity. Major histocompatibility complex (MHC) genes in his family showed that the proband had the MHC haplotypes HLA-A25, B18, DR2, DQ1, SQ042/HLA-A24, B18, DR2, DQ1, SQ042. A strong genetic linkage of the deficiency of the second component of the complement gene and the HLA antigens A25, B18, and DR2, is well established in Caucasian populations. This suggests that the probable origin of the deficiency in our patient was admixture with Caucasian ancestors.
AB - Hereditary deficiency of the second component of the complement system is an uncommon condition that has been reported so far mostly in Caucasians. We describe a Mexican patient with undetectable C2 levels and absence of complement hemolytic activity. Major histocompatibility complex (MHC) genes in his family showed that the proband had the MHC haplotypes HLA-A25, B18, DR2, DQ1, SQ042/HLA-A24, B18, DR2, DQ1, SQ042. A strong genetic linkage of the deficiency of the second component of the complement gene and the HLA antigens A25, B18, and DR2, is well established in Caucasian populations. This suggests that the probable origin of the deficiency in our patient was admixture with Caucasian ancestors.
KW - C2-deficiency
KW - Complement genes
KW - Mayor histocompatibility complex
KW - Mexican population
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M3 - Article
C2 - 8966394
AN - SCOPUS:0030184963
VL - 48
SP - 307
EP - 309
JO - Revista de Investigacion Clinica
JF - Revista de Investigacion Clinica
SN - 0034-8376
IS - 4
ER -