Major histocompatibility complex genes in a Mexican family with deficiency of the second component of the complement system

Héctor Melín-Aldana, Pedro Reyes, Gilberto Vargas-Alarcón, Jesús K. Yamamoto-Furusho, Julio Granados*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Hereditary deficiency of the second component of the complement system is an uncommon condition that has been reported so far mostly in Caucasians. We describe a Mexican patient with undetectable C2 levels and absence of complement hemolytic activity. Major histocompatibility complex (MHC) genes in his family showed that the proband had the MHC haplotypes HLA-A25, B18, DR2, DQ1, SQ042/HLA-A24, B18, DR2, DQ1, SQ042. A strong genetic linkage of the deficiency of the second component of the complement gene and the HLA antigens A25, B18, and DR2, is well established in Caucasian populations. This suggests that the probable origin of the deficiency in our patient was admixture with Caucasian ancestors.

Original languageEnglish (US)
Pages (from-to)307-309
Number of pages3
JournalRevista de Investigacion Clinica
Volume48
Issue number4
StatePublished - Jul 1 1996

Keywords

  • C2-deficiency
  • Complement genes
  • Mayor histocompatibility complex
  • Mexican population

ASJC Scopus subject areas

  • Medicine(all)

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