TY - JOUR
T1 - Making a mountain out of a Molehill
T2 - NRAS, mosaicism, and large congenital nevi
AU - Gerami, Pedram
AU - Paller, Amy S.
PY - 2013/9
Y1 - 2013/9
N2 - Linking phenotypic patterns of melanocytic neoplasia to specific gene mutations allows more precise predicting of clinical behavior and response to targeted therapy. In this issue, Kinsler et al. provide evidence that multiple congenital nevi with central nervous system lesions are likely exclusively the result of mosaic mutations in NRAS. We discuss the link between mosaic NRAS mutations, cellular senescence, and clinical phenotype in these nevi.
AB - Linking phenotypic patterns of melanocytic neoplasia to specific gene mutations allows more precise predicting of clinical behavior and response to targeted therapy. In this issue, Kinsler et al. provide evidence that multiple congenital nevi with central nervous system lesions are likely exclusively the result of mosaic mutations in NRAS. We discuss the link between mosaic NRAS mutations, cellular senescence, and clinical phenotype in these nevi.
UR - http://www.scopus.com/inward/record.url?scp=84884365535&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884365535&partnerID=8YFLogxK
U2 - 10.1038/jid.2013.146
DO - 10.1038/jid.2013.146
M3 - Comment/debate
C2 - 23949765
AN - SCOPUS:84884365535
VL - 133
SP - 2127
EP - 2130
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 9
ER -