Making a mountain out of a Molehill: NRAS, mosaicism, and large congenital nevi

Pedram Gerami, Amy S. Paller*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

20 Scopus citations

Abstract

Linking phenotypic patterns of melanocytic neoplasia to specific gene mutations allows more precise predicting of clinical behavior and response to targeted therapy. In this issue, Kinsler et al. provide evidence that multiple congenital nevi with central nervous system lesions are likely exclusively the result of mosaic mutations in NRAS. We discuss the link between mosaic NRAS mutations, cellular senescence, and clinical phenotype in these nevi.

Original languageEnglish (US)
Pages (from-to)2127-2130
Number of pages4
JournalJournal of Investigative Dermatology
Volume133
Issue number9
DOIs
StatePublished - Sep 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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