@article{77c31da45709418391b7871c10318d82,
title = "Making the case for chromatin profiling: A new tool to investigate the immune-regulatory landscape",
abstract = "Recent technological advances have enabled researchers to accurately and efficiently assay the chromatin dynamics of scarce cell populations. In this Opinion article, we advocate the application of these technologies to central questions in immunology. Unlike changes to other molecular structures in the cell, chromatin features can reveal the past (developmental history), present (current activity) and future (potential response to challenges) of a given immune cell type; chromatin profiling is therefore an important new tool for studying the immune-regulatory networks of health and disease.",
author = "Winter, {Deborah R.} and Steffen Jung and Ido Amit",
note = "Funding Information: The authors thank G. Brodsky for drafting the artwork. Research in the laboratory of I.A. is supported by the European Research Council (309788) and the Israeli Science Foundation (712163), The Ernest and Bonnie Beutler Research Program of Excellence in Genomic Medicine and the Center for Excellence in Genome Science from the National Human Genome Research I n s t i t u t e ( N H G R I; 1P50HG006193). Research in the laboratory of S.J. is supported by the Israeli Science Foundation (887/11), the European Research Council (340345) and the Deutsche Forschungsgemeinschaft (FOR1336). D.R.W. is grateful to the Azrieli Foundation for the Azrieli Fellowship award and for support from the European Molecular Biology Organization (EMBO; ALT766-2014) and the European Commission FP7 (Marie Curie Actions, EMBOCOFUND2012, GA-2012-600394). Publisher Copyright: {\textcopyright} 2015 Macmillan Publishers Limited.",
year = "2015",
month = sep,
day = "25",
doi = "10.1038/nri3884",
language = "English (US)",
volume = "15",
pages = "585--594",
journal = "Nature Reviews Immunology",
issn = "1474-1733",
publisher = "Nature Publishing Group",
number = "9",
}