Making the case for chromatin profiling: A new tool to investigate the immune-regulatory landscape

Deborah R. Winter*, Steffen Jung, Ido Amit

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Recent technological advances have enabled researchers to accurately and efficiently assay the chromatin dynamics of scarce cell populations. In this Opinion article, we advocate the application of these technologies to central questions in immunology. Unlike changes to other molecular structures in the cell, chromatin features can reveal the past (developmental history), present (current activity) and future (potential response to challenges) of a given immune cell type; chromatin profiling is therefore an important new tool for studying the immune-regulatory networks of health and disease.

Original languageEnglish (US)
Pages (from-to)585-594
Number of pages10
JournalNature Reviews Immunology
Volume15
Issue number9
DOIs
StatePublished - Sep 25 2015

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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