Making the Case: Intra-arterial Therapy for Less Common Metastases

Andrew C. Gordon, Omar M. Uddin, Ahsun Riaz, Riad Salem, Robert J Lewandowski*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Intra-arterial therapies have high antitumor activity for both primary and secondary hepatic malignancies. Selective infusions allow increased delivery of cytoreductive therapy to the tumor bed while sparing the normal hepatic parenchyma. These therapies are now often applied in the outpatient setting or with short overnight hospital stays and have a growing role in the treatment of liver-dominant disease from metastatic colorectal cancer and from neuroendocrine tumors. Less commonly, intra-arterial therapies are applied to treat secondary hepatic malignancies from breast cancer, melanoma, pancreatic adenocarcinoma, and soft-tissue sarcomas. The available data are limited and generally retrospective observational cohort series of single institutions. The purpose of this article is to summarize the recent literature on outcomes for intra-arterial therapy in nonsurgical patients. Multi-institutional registries and prospective data are greatly needed, as intra-arterial therapies are increasingly applied in these patients to stop progression of chemorefractory tumors.

Original languageEnglish (US)
Pages (from-to)132-139
Number of pages8
JournalSeminars in Interventional Radiology
Volume34
Issue number2
DOIs
StatePublished - Jun 1 2017

Fingerprint

Neoplasm Metastasis
Therapeutics
Liver
Neoplasms
Neuroendocrine Tumors
Sarcoma
Registries
Liver Diseases
Colorectal Neoplasms
Melanoma
Length of Stay
Adenocarcinoma
Outpatients
Breast Neoplasms

Keywords

  • chemoembolization
  • hepatic artery infusion chemotherapy
  • interventional radiology
  • liver metastases
  • radioembolization

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Making the Case: Intra-arterial Therapy for Less Common Metastases",
abstract = "Intra-arterial therapies have high antitumor activity for both primary and secondary hepatic malignancies. Selective infusions allow increased delivery of cytoreductive therapy to the tumor bed while sparing the normal hepatic parenchyma. These therapies are now often applied in the outpatient setting or with short overnight hospital stays and have a growing role in the treatment of liver-dominant disease from metastatic colorectal cancer and from neuroendocrine tumors. Less commonly, intra-arterial therapies are applied to treat secondary hepatic malignancies from breast cancer, melanoma, pancreatic adenocarcinoma, and soft-tissue sarcomas. The available data are limited and generally retrospective observational cohort series of single institutions. The purpose of this article is to summarize the recent literature on outcomes for intra-arterial therapy in nonsurgical patients. Multi-institutional registries and prospective data are greatly needed, as intra-arterial therapies are increasingly applied in these patients to stop progression of chemorefractory tumors.",
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Making the Case : Intra-arterial Therapy for Less Common Metastases. / Gordon, Andrew C.; Uddin, Omar M.; Riaz, Ahsun; Salem, Riad; Lewandowski, Robert J.

In: Seminars in Interventional Radiology, Vol. 34, No. 2, 01.06.2017, p. 132-139.

Research output: Contribution to journalArticle

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T2 - Intra-arterial Therapy for Less Common Metastases

AU - Gordon, Andrew C.

AU - Uddin, Omar M.

AU - Riaz, Ahsun

AU - Salem, Riad

AU - Lewandowski, Robert J

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AB - Intra-arterial therapies have high antitumor activity for both primary and secondary hepatic malignancies. Selective infusions allow increased delivery of cytoreductive therapy to the tumor bed while sparing the normal hepatic parenchyma. These therapies are now often applied in the outpatient setting or with short overnight hospital stays and have a growing role in the treatment of liver-dominant disease from metastatic colorectal cancer and from neuroendocrine tumors. Less commonly, intra-arterial therapies are applied to treat secondary hepatic malignancies from breast cancer, melanoma, pancreatic adenocarcinoma, and soft-tissue sarcomas. The available data are limited and generally retrospective observational cohort series of single institutions. The purpose of this article is to summarize the recent literature on outcomes for intra-arterial therapy in nonsurgical patients. Multi-institutional registries and prospective data are greatly needed, as intra-arterial therapies are increasingly applied in these patients to stop progression of chemorefractory tumors.

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