Making the diagnosis of frontotemporal lobar degeneration

Eileen H. Bigio*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Context. - Autopsy evaluation of the brain of a patient with frontotemporal dementia (FTD) can be daunting to the general pathologist. At some point in their training, most pathologists learn about Pick disease, and can recognize Pick bodies, the morphologic hallmark of Pick disease. Pick disease is a type of frontotemporal lobar degeneration (FTLD), the general category of pathologic process underlying most cases of FTD. The 2 major categories of pathologic FTLD are tauopathies (FTLD-tau) and ubiquitinopathies (FTLD-U). Pick disease is one of the FTLD-tau subtypes and is termed FTLD-tau (PiD). Objective. - To "demystify" FTLDs, and to demonstrate that subtypes of FTLD-tau and FTLD-U can be easily determined by following a logical, stepwise, histochemical, and immunohistochemical investigation of the FTD autopsy brain. Data Sources. - Previously published peer-reviewed articles. Conclusions. - The hope is that this article will be a useful reference for the general pathologist faced with performing a brain autopsy on a decedent with frontotemporal dementia.

Original languageEnglish (US)
Pages (from-to)314-325
Number of pages12
JournalArchives of Pathology and Laboratory Medicine
Issue number3
StatePublished - Mar 2013

ASJC Scopus subject areas

  • Medical Laboratory Technology
  • Pathology and Forensic Medicine


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