Male pediatric, adolescent, and young adult reproductive survivorship

Karen Burns*, Christine Phillips, Robert Brannigan, Anna Franklin, Jonathan Howell, Deb Schmidt, Jenna Sopfe, Leslie Coker Appiah, Antoinette Anazodo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


As pediatric, adolescent, and young adult cancer survival rates increase, emphasis is placed on reducing late effects, including reproductive complications and potential impact to fertility. Male survivors are at risk of abnormalities in sperm, hormone deficiencies, and sexual dysfunction. This can impact one's progression into puberty and ability to have a biological child and impacts quality of life following treatment. Access to reproductive care is important and requires patient assessment and appropriate referral to reproductive specialists. This review addresses reproductive complications associated with therapy, standard-of-care testing, and therapeutic interventions. The psychologic impact on psychosexual functioning is also addressed.

Original languageEnglish (US)
Article numbere28823
JournalPediatric Blood and Cancer
Issue numberS5
StatePublished - Sep 2023


  • cancer survivor
  • childhood cancer
  • late effects
  • male fertility
  • male gonadotoxicity

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health


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