Malignancies in juvenile idiopathic arthritis: A preliminary report

Sasha Bernatsky*, Alan M. Rosenberg, Kiem G. Oen, Ciaran M. Duffy, Rosalind Ramsey-Goldman, Jeremy Labrecque, Yvan St. Pierre, Ann E. Clarke

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Objective. To present preliminary data on incidence of malignancy in juvenile idiopathic arthritis (JIA), compared to general population rates. Methods. We examined cancer occurrence within JIA registries at 3 Canadian pediatric rheumatology centers. The subjects in the clinic registries were linked to regional tumor registries to determine the occurrence of invasive cancers over the observation period (spanning 1974-2006). The total number of cancers expected was determined by multiplying the person-years in the cohort by age, sex, and calendar year-specific cancer rates. The standardized incidence ratio (SIR, ratio of cancers observed to expected) was generated, with 95% confidence intervals. Results. The study sample consisted of 1834 patients. The female proportion was 67.6%; average age at entry to cohort was 8.6 years (SD 5.1). The majority were Caucasian. Subjects contributed 22,341 patient-years (average 12.2, SD 7.8). Within this observation period, one invasive cancer occurred, compared to 7.9 expected (SIR 0.12, 95% CI 0.0, 0.70). This was a hematological cancer (Hodgkin's lymphoma), representing a SIR for hematological malignancies of 0.76 (95% CI 0.02, 4.21). Conclusion. Only one invasive cancer was identified in this large sample of individuals with JIA, observed for an average of 12.2 years each. These data suggest that, at least in the initial years following diagnosis of JIA, the risk of invasive cancers overall is not markedly increased. The results do not rule out the possibility of a baseline increased risk of hematological malignancies. The Journal of Rheumatology

Original languageEnglish (US)
Pages (from-to)760-763
Number of pages4
JournalJournal of Rheumatology
Volume38
Issue number4
DOIs
StatePublished - Apr 2011

Keywords

  • Cancer
  • Incidence
  • Juvenile idiopathic arthritis
  • Malignancies

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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