Malignancies in systemic lupus erythematosus

Mruganka Kale; Rosalind Ramsey-Goldman; Caroline Gordon; Ann E. Clarke; Sasha Bernatsky

doi:10.2217/ijr.13.11

Malignancies in systemic lupus erythematosus

Mruganka Kale, Rosalind Ramsey-Goldman, Caroline Gordon, Ann E. Clarke, Sasha Bernatsky^*

^*Corresponding author for this work

Medicine, Rheumatology Division

Research output: Contribution to journal › Review article › peer-review

Abstract

The purpose of this review is to underline important advancements in the understanding of cancer risks in systemic lupus erythematosus (SLE). In SLE, there is an increased risk of specific kinds of malignancy. For example, the risk of non-Hodgkin's lymphoma is increased several-fold in SLE versus the general population. In addition, heightened risks for lung cancer, thyroid cancer and cervical dysplasia in SLE have been found. Some have postulated that immunosuppressive drugs play a role, as well as other important mediators, such as lupus disease activity itself. One new frontier being explored is the significant finding of a decreased risk of certain nonhematologic cancers (e.g., breast, ovarian, endometrial and prostate) in SLE. The reasons for this are currently under study.

Original language	English (US)
Pages (from-to)	275-280
Number of pages	6
Journal	International Journal of Clinical Rheumatology
Volume	8
Issue number	2
DOIs	https://doi.org/10.2217/ijr.13.11
State	Published - Apr 1 2013

Keywords

cancer
immunosuppressive drug
malignancy
risk
systemic lupus erythematosus

ASJC Scopus subject areas

Rheumatology

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title = "Malignancies in systemic lupus erythematosus",

abstract = "The purpose of this review is to underline important advancements in the understanding of cancer risks in systemic lupus erythematosus (SLE). In SLE, there is an increased risk of specific kinds of malignancy. For example, the risk of non-Hodgkin's lymphoma is increased several-fold in SLE versus the general population. In addition, heightened risks for lung cancer, thyroid cancer and cervical dysplasia in SLE have been found. Some have postulated that immunosuppressive drugs play a role, as well as other important mediators, such as lupus disease activity itself. One new frontier being explored is the significant finding of a decreased risk of certain nonhematologic cancers (e.g., breast, ovarian, endometrial and prostate) in SLE. The reasons for this are currently under study.",

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AU - Ramsey-Goldman, Rosalind

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AB - The purpose of this review is to underline important advancements in the understanding of cancer risks in systemic lupus erythematosus (SLE). In SLE, there is an increased risk of specific kinds of malignancy. For example, the risk of non-Hodgkin's lymphoma is increased several-fold in SLE versus the general population. In addition, heightened risks for lung cancer, thyroid cancer and cervical dysplasia in SLE have been found. Some have postulated that immunosuppressive drugs play a role, as well as other important mediators, such as lupus disease activity itself. One new frontier being explored is the significant finding of a decreased risk of certain nonhematologic cancers (e.g., breast, ovarian, endometrial and prostate) in SLE. The reasons for this are currently under study.

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