Malignant astrocytic glioma: Genetics, biology, and paths to treatment

Frank B. Furnari, Tim Fenton, Robert M. Bachoo, Akitake Mukasa, Jayne M. Stommel, Alexander Stegh, William C. Hahn, Keith L. Ligon, David N. Louis, Cameron Brennan, Lynda Chin, Ronald A. DePinho*, Webster K. Cavenee

*Corresponding author for this work

Research output: Contribution to journalReview article

1550 Scopus citations

Abstract

Malignant astrocytic gliomas such as glioblastoma are the most common and lethal intracranial tumors. These cancers exhibit a relentless malignant progression characterized by widespread invasion throughout the brain, resistance to traditional and newer targeted therapeutic approaches, destruction of normal brain tissue, and certain death. The recent confluence of advances in stem cell biology, cell signaling, genome and computational science and genetic model systems have revolutionized our understanding of the mechanisms underlying the genetics, biology and clinical behavior of glioblastoma. This progress is fueling new opportunities for understanding the fundamental basis for development of this devastating disease and also novel therapies that, for the first time, portend meaningful clinical responses.

Original languageEnglish (US)
Pages (from-to)2683-2710
Number of pages28
JournalGenes and Development
Volume21
Issue number21
DOIs
StatePublished - Nov 1 2007

Keywords

  • Cancer stem cells
  • Genetically engineered models
  • Glioblastoma
  • Glioma
  • Neural stem cells
  • Tyrosine kinase inhibitor

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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    Furnari, F. B., Fenton, T., Bachoo, R. M., Mukasa, A., Stommel, J. M., Stegh, A., Hahn, W. C., Ligon, K. L., Louis, D. N., Brennan, C., Chin, L., DePinho, R. A., & Cavenee, W. K. (2007). Malignant astrocytic glioma: Genetics, biology, and paths to treatment. Genes and Development, 21(21), 2683-2710. https://doi.org/10.1101/gad.1596707