Malignant astrocytoma in elderly patients: Where do we stand?

Ghazaleh Tabatabai; Roger Stupp; Wolfgang Wick; Michael Weller

doi:10.1097/WCO.0000000000000037

Malignant astrocytoma in elderly patients: Where do we stand?

Ghazaleh Tabatabai^*, Roger Stupp, Wolfgang Wick, Michael Weller

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Summary Current standard of care for elderly patients with malignant astrocytoma involves a treatment strategy based on the MGMT gene promoter methylation status. The role of combined radiotherapy and TMZ chemotherapy and a potential role for the addition of anti-VEGF therapy to radiotherapy are currently addressed in ongoing trials. The lack of favorable prognostic factors in tumor tissue might in part explain the poorer clinical outcome of elderly patients.

Original language	English (US)
Pages (from-to)	693-700
Number of pages	8
Journal	Current Opinion in Neurology
Volume	26
Issue number	6
DOIs	https://doi.org/10.1097/WCO.0000000000000037
State	Published - Dec 2013

Keywords

Clinical trial
Elderly patients
Malignant astrocytoma
Molecular signature

ASJC Scopus subject areas

Clinical Neurology
Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/WCO.0000000000000037

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title = "Malignant astrocytoma in elderly patients: Where do we stand?",

abstract = "Summary Current standard of care for elderly patients with malignant astrocytoma involves a treatment strategy based on the MGMT gene promoter methylation status. The role of combined radiotherapy and TMZ chemotherapy and a potential role for the addition of anti-VEGF therapy to radiotherapy are currently addressed in ongoing trials. The lack of favorable prognostic factors in tumor tissue might in part explain the poorer clinical outcome of elderly patients.",

keywords = "Clinical trial, Elderly patients, Malignant astrocytoma, Molecular signature",

author = "Ghazaleh Tabatabai and Roger Stupp and Wolfgang Wick and Michael Weller",

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T1 - Malignant astrocytoma in elderly patients

T2 - Where do we stand?

AU - Tabatabai, Ghazaleh

AU - Stupp, Roger

AU - Wick, Wolfgang

AU - Weller, Michael

PY - 2013/12

Y1 - 2013/12

N2 - Summary Current standard of care for elderly patients with malignant astrocytoma involves a treatment strategy based on the MGMT gene promoter methylation status. The role of combined radiotherapy and TMZ chemotherapy and a potential role for the addition of anti-VEGF therapy to radiotherapy are currently addressed in ongoing trials. The lack of favorable prognostic factors in tumor tissue might in part explain the poorer clinical outcome of elderly patients.

AB - Summary Current standard of care for elderly patients with malignant astrocytoma involves a treatment strategy based on the MGMT gene promoter methylation status. The role of combined radiotherapy and TMZ chemotherapy and a potential role for the addition of anti-VEGF therapy to radiotherapy are currently addressed in ongoing trials. The lack of favorable prognostic factors in tumor tissue might in part explain the poorer clinical outcome of elderly patients.

KW - Clinical trial

KW - Elderly patients

KW - Malignant astrocytoma

KW - Molecular signature

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ER -

Malignant astrocytoma in elderly patients: Where do we stand?

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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