Malignant Glioma Physiology: Cellular Response to Hypoxia and Its Role in Tumor Progression

Daniel J. Brat*, Timothy B. Mapstone

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

92 Scopus citations

Abstract

Malignant gliomas have invasive properties that make them nearly impossible to cure surgically. Most physicians agree that the best hope for long-term control lies with adjunctive therapies. One emerging field of research attempts to limit tumor growth by interfering with vascular proliferation that occurs as a physiologic response to hypoxia within the tumor.

Original languageEnglish (US)
Pages (from-to)659-668
Number of pages10
JournalAnnals of Internal Medicine
Volume138
Issue number8
DOIs
StatePublished - Apr 15 2003

ASJC Scopus subject areas

  • Medicine(all)

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