Malignant glioma progression and nitric oxide

Dora Lam-Himlin, Michael G. Espey, George Perry, Mark A. Smith, Rudy J. Castellani*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Glioblastoma multiforme, the most common of the malignant gliomas, carries a dismal prognosis in spite of the most aggressive therapy and recent advances in molecular pathways of glioma progression. Although it has received relatively little attention in the setting of malignant gliomas, nitric oxide metabolism may be intimately associated with the disease process. Interestingly, nitric oxide has both physiological roles (e.g., neurotransmitter-like activity, stimulation of cyclic GMP), and pathophysiological roles (e.g., neoplastic transformation, tumor neovascularization, induction of apoptosis, free radical damage). Moreover, whether nitric oxide is neuroprotective or neurotoxic in a given disease state, or whether it enhances or diminishes chemotherapeutic efficacy in malignant neoplasia, is unresolved. This review discusses the multifaceted activity of nitric oxide with particular reference to malignant gliomas.

Original languageEnglish (US)
Pages (from-to)764-768
Number of pages5
JournalNeurochemistry International
Issue number8
StatePublished - Dec 2006


  • Glioblastoma multiforme
  • Glioma
  • Nitric oxide
  • Nitric oxide synthase

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology


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