Malignant Gliomas in Adulthood

Michael Ivan*, Matthew Tate, Jennifer L. Clarke

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Malignant gliomas are the most common type of primary malignant brain tumor, and glioblastoma is the most common malignant glioma. Standard initial therapy for glioblastoma includes aggressive surgical resection followed by a combination of focal radiation and chemotherapy with temozolomide; the role for chemotherapy in initial treatment of other malignant gliomas is less clear. Prognosis is poor, and recurrence of any malignant glioma is almost universal. This chapter provides an overview of malignant gliomas, their treatment, and ongoing research looking for more effective treatments.

Original languageEnglish (US)
Title of host publicationNeuro-oncology
Subtitle of host publicationFirst Edition
PublisherBlackwell Publishing Ltd
Number of pages15
ISBN (Print)9780470655757
StatePublished - Feb 29 2012


  • Anaplastic astrocytoma
  • Anaplastic oligodendroglioma
  • Bevacizumab
  • Chemotherapy
  • Glioblastoma
  • Malignant glioma
  • Pseudoprogression
  • Radiation therapy
  • Surgery
  • Temozolomide

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)


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