Malignant lymphoma of the skin in children

Ghazi S. Zaatari, Wing C. Chan*, Tae H. Kim, Douglas L. Williams, Morris Kletzel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The clinical and histopathologic findings in eight cases of malignant lymphoma of the skin in children are presented. All patients had skin lesions as a primary manifestation of the disorder. Three patients had simultaneous regional lymph node involvement documented by the findings of subsequent biopsies. The majority (five patients) had solitary nodules involving the skin of the head and neck region. Three of the skin biopsy specimens were classified as lymphoblastic lymphoma, two large cell lymphoma, two mixed small and large cell lymphoma, and one small cleaved cell lymphoma. Disseminated disease subsequently developed in four patients in an interval that ranged from 4 to 30 months after diagnosis. The follow‐up period ranged from 8 to 56 months, and median survival was 56 months. A literature review of 33 previously reported patients and our eight patients indicate that: (1) skin of the head and the neck region is the most common site of involvement (56%); (2) the majority of lymphomas are diffuse (93%); (3) lymphoblastic lymphoma is the predominant type (53%), with a high proportion showing a non‐T‐cell phenotype; (4) Burkitt's lymphoma and Hodgkin's disease of the skin are extremely rare; and (5) most patients presented in an early clinical stage (Stage IE 56%, Stage IIE 21%), and prolonged disease‐free survival was seen mostly in Stage I patients. The cumulative probability of survival for Stage I patients at 24 months was 0.71; while for Stages II to IV patients combined, it was 0.33 at 26 months. Cancer 59:1040‐1045, 1987.

Original languageEnglish (US)
Pages (from-to)1040-1045
Number of pages6
Issue number5
StatePublished - Mar 1 1987

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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