Malignant lymphoma presenting with cutaneous granulomas

Kevin M. Diette; William A. Caro; Henry H. Roenigk

doi:10.1016/S0190-9622(84)80442-9

Malignant lymphoma presenting with cutaneous granulomas

Kevin M. Diette^*, William A. Caro, Henry H. Roenigk

^*Corresponding author for this work

Dermatology

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

A 49-year-old man with fever, malaise, weight loss, and pneumonia developed cutaneous nodules and neurologic symptoms. Skin biopsy studies revealed granulomatous inflammation consistent with a sarcoid reaction, and mild granulomatous changes were noted on biopsy specimens of liver and bone marrow. A lymph node biopsy was unremarkable. Neurologic deterioration prompted an extensive workup that revealed an intracranial mass. A brain biopsy study revealed malignant lymphoma, large cell type. Autopsy study confirmed the diagnosis and showed no evidence of granulomatous infiltrates. The cutaneous granulomas represent a nonspecific immune response possibly related to the underlying lymphoma. The relationship between sarcoidosis and sarcoid reactions and lymphoma is discussed.

Original language	English (US)
Pages (from-to)	896-902
Number of pages	7
Journal	Journal of the American Academy of Dermatology
Volume	10
Issue number	5
DOIs	https://doi.org/10.1016/S0190-9622(84)80442-9
State	Published - Jan 1 1984

ASJC Scopus subject areas

Dermatology

Access to Document

10.1016/S0190-9622(84)80442-9

Cite this

@article{315f493d1d894e79941c958cfecc2b5a,

title = "Malignant lymphoma presenting with cutaneous granulomas",

abstract = "A 49-year-old man with fever, malaise, weight loss, and pneumonia developed cutaneous nodules and neurologic symptoms. Skin biopsy studies revealed granulomatous inflammation consistent with a sarcoid reaction, and mild granulomatous changes were noted on biopsy specimens of liver and bone marrow. A lymph node biopsy was unremarkable. Neurologic deterioration prompted an extensive workup that revealed an intracranial mass. A brain biopsy study revealed malignant lymphoma, large cell type. Autopsy study confirmed the diagnosis and showed no evidence of granulomatous infiltrates. The cutaneous granulomas represent a nonspecific immune response possibly related to the underlying lymphoma. The relationship between sarcoidosis and sarcoid reactions and lymphoma is discussed.",

author = "Diette, {Kevin M.} and Caro, {William A.} and Roenigk, {Henry H.}",

year = "1984",

month = jan,

day = "1",

doi = "10.1016/S0190-9622(84)80442-9",

language = "English (US)",

volume = "10",

pages = "896--902",

journal = "Journal of the American Academy of Dermatology",

issn = "0190-9622",

publisher = "Mosby Inc.",

number = "5",

}

TY - JOUR

T1 - Malignant lymphoma presenting with cutaneous granulomas

AU - Diette, Kevin M.

AU - Caro, William A.

AU - Roenigk, Henry H.

PY - 1984/1/1

Y1 - 1984/1/1

N2 - A 49-year-old man with fever, malaise, weight loss, and pneumonia developed cutaneous nodules and neurologic symptoms. Skin biopsy studies revealed granulomatous inflammation consistent with a sarcoid reaction, and mild granulomatous changes were noted on biopsy specimens of liver and bone marrow. A lymph node biopsy was unremarkable. Neurologic deterioration prompted an extensive workup that revealed an intracranial mass. A brain biopsy study revealed malignant lymphoma, large cell type. Autopsy study confirmed the diagnosis and showed no evidence of granulomatous infiltrates. The cutaneous granulomas represent a nonspecific immune response possibly related to the underlying lymphoma. The relationship between sarcoidosis and sarcoid reactions and lymphoma is discussed.

AB - A 49-year-old man with fever, malaise, weight loss, and pneumonia developed cutaneous nodules and neurologic symptoms. Skin biopsy studies revealed granulomatous inflammation consistent with a sarcoid reaction, and mild granulomatous changes were noted on biopsy specimens of liver and bone marrow. A lymph node biopsy was unremarkable. Neurologic deterioration prompted an extensive workup that revealed an intracranial mass. A brain biopsy study revealed malignant lymphoma, large cell type. Autopsy study confirmed the diagnosis and showed no evidence of granulomatous infiltrates. The cutaneous granulomas represent a nonspecific immune response possibly related to the underlying lymphoma. The relationship between sarcoidosis and sarcoid reactions and lymphoma is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0021268473&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021268473&partnerID=8YFLogxK

U2 - 10.1016/S0190-9622(84)80442-9

DO - 10.1016/S0190-9622(84)80442-9

M3 - Article

C2 - 6725676

AN - SCOPUS:0021268473

SN - 0190-9622

VL - 10

SP - 896

EP - 902

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

IS - 5

ER -

Malignant lymphoma presenting with cutaneous granulomas

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this