Malignant lymphoma presenting with cutaneous granulomas

Kevin M. Diette*, William A. Caro, Henry H. Roenigk

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


A 49-year-old man with fever, malaise, weight loss, and pneumonia developed cutaneous nodules and neurologic symptoms. Skin biopsy studies revealed granulomatous inflammation consistent with a sarcoid reaction, and mild granulomatous changes were noted on biopsy specimens of liver and bone marrow. A lymph node biopsy was unremarkable. Neurologic deterioration prompted an extensive workup that revealed an intracranial mass. A brain biopsy study revealed malignant lymphoma, large cell type. Autopsy study confirmed the diagnosis and showed no evidence of granulomatous infiltrates. The cutaneous granulomas represent a nonspecific immune response possibly related to the underlying lymphoma. The relationship between sarcoidosis and sarcoid reactions and lymphoma is discussed.

Original languageEnglish (US)
Pages (from-to)896-902
Number of pages7
JournalJournal of the American Academy of Dermatology
Issue number5
StatePublished - 1984

ASJC Scopus subject areas

  • Dermatology


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