Malignant melanoma arising in a primary mediastinal germ cell tumor

Sherry Lee*, Yevgen Chornenkyy, Michael T. Swete, Samuel S. Kim, Ankit Bharat, Ximing J. Yang, Anjana Yeldandi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Primary mediastinal germ cell tumors with somatic malignancies are rare. We report a case of a 34-year old man with melanoma arising in a primary mediastinal mixed germ cell tumor. On initial biopsy, the patient was found to have a germ cell tumor containing yolk sac and embryonal components only. After chemotherapy, histopathological evaluation of the residual tumor in the wide local resection specimen revealed a mature teratoma with melanoma. Molecular studies demonstrated that the residual germ cell tumor harbored KIT and NRAS mutations associated with malignant melanoma.

Original languageEnglish (US)
Article number153210
JournalPathology Research and Practice
Issue number11
StatePublished - Nov 2020


  • KIT
  • Mediastinal germ cell tumor
  • Melanoma
  • Molecular analysis
  • NRAS
  • Teratoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology


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