Abstract
Lasiocarpine, a pyrrolizidine alkaloid, was fed at a dietary concentration of 50/10(6) for 55 weeks, to 20 male F-344 rats. Malignant tumours developed in 17/20 animals between 48 and 59 weeks. Forty-five percent (9/20) developed angiosarcomas of the liver and 35% (7/20) had hepatocellular carcinomas. Other tumours included malignant adnexas tumour of the skin (1 rat) and lympohoma (1 rat). Lung metastases were observed in 4 animals with angiosarcoma of the liver and one animal with hepatocellular carcinoma. From one animal, angiosarcoma was successfully transplanted through 4 generations.
Original language | English (US) |
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Pages (from-to) | 289-293 |
Number of pages | 5 |
Journal | British Journal of Cancer |
Volume | 37 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1978 |
ASJC Scopus subject areas
- Oncology
- Cancer Research