Malignant neoplasms in rats fed lasiocarpine

M. S. Rao; Janardan K Reddy

doi:10.1038/bjc.1978.38

Malignant neoplasms in rats fed lasiocarpine

M. S. Rao, Janardan K Reddy

Pathology

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Lasiocarpine, a pyrrolizidine alkaloid, was fed at a dietary concentration of 50/10(6) for 55 weeks, to 20 male F-344 rats. Malignant tumours developed in 17/20 animals between 48 and 59 weeks. Forty-five percent (9/20) developed angiosarcomas of the liver and 35% (7/20) had hepatocellular carcinomas. Other tumours included malignant adnexas tumour of the skin (1 rat) and lympohoma (1 rat). Lung metastases were observed in 4 animals with angiosarcoma of the liver and one animal with hepatocellular carcinoma. From one animal, angiosarcoma was successfully transplanted through 4 generations.

Original language	English (US)
Pages (from-to)	289-293
Number of pages	5
Journal	British Journal of Cancer
Volume	37
Issue number	2
DOIs	https://doi.org/10.1038/bjc.1978.38
State	Published - Feb 1978

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/bjc.1978.38

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AB - Lasiocarpine, a pyrrolizidine alkaloid, was fed at a dietary concentration of 50/10(6) for 55 weeks, to 20 male F-344 rats. Malignant tumours developed in 17/20 animals between 48 and 59 weeks. Forty-five percent (9/20) developed angiosarcomas of the liver and 35% (7/20) had hepatocellular carcinomas. Other tumours included malignant adnexas tumour of the skin (1 rat) and lympohoma (1 rat). Lung metastases were observed in 4 animals with angiosarcoma of the liver and one animal with hepatocellular carcinoma. From one animal, angiosarcoma was successfully transplanted through 4 generations.

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Malignant neoplasms in rats fed lasiocarpine

Abstract

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