Malondialdehyde-Modified LDL IgG Antibody Levels and Indices of Cardiac Function in Valvular Heart and Coronary Artery Disease Patients

Amir Ali Rahsepar, Asadollah Mirzaee, Fatemeh Moodi, Mohsen Moohebati, Shima Tavallaie, Fatemeh Khorashadizadeh, Behrooz Mottahedi, Jamil Esfehanizadeh, Ali Azari, Roshanak Khojasteh, Somayeh Mousavi, Roghayeh Paydar, Maral Amini, Majid Ghayour-Mobarhan, Gordon A. Ferns, Amirhossein Sahebkar

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objective: To compare the changes in anti-malondialdehyde-modified low-density lipoprotein (MDA-LDL) IgG levels among patients undergoing off-pump and on-pump coronary artery bypass grafting (CABG) or valvuloplasty. Subjects and Methods: A total of 38, 39 and 34 patients who underwent off-pump CABG, on-pump CABG and valvuloplasty, respectively, were enrolled in this study. Serum anti-MDA-LDL IgG values were measured 24 h before and after the operative procedures and at discharge. Echocardiography was also done before surgery and before discharge. The results were compared with values from 50 healthy controls. Results: In all patients, a reduction in antibody titers was observed post-operatively. However, the decrease was significant only in the off-pump CABG - before surgery: 42.33 (25.83-58.51), after surgery: 30.86 (16.36-51.33) and at discharge: 10.96 (6.82-23.57; p = 0.027). There was a significant positive association between anti-MDA-LDL IgG levels and ejection fraction (r = 0.248, p = 0.036) and a negative association with E/E', a marker of pulmonary capillary wedge pressure, in the coronary patients (r = -0.345, p = 0.012), but no significant associations were found in patients with valvular heart disease. Conclusions: Serum anti-MDA-LDL IgG levels were associated with cardiac function indices in coronary patients undergoing CABG.

Original languageEnglish (US)
Pages (from-to)424-431
Number of pages8
JournalMedical Principles and Practice
Volume24
Issue number5
DOIs
StatePublished - Jul 25 2015

Keywords

  • Anti-malondialdehyde-modified low-density lipoprotein
  • Cardiac function
  • Coronary artery bypass grafting
  • Valvular heart disease

ASJC Scopus subject areas

  • General Medicine

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