Management of glioblastoma in elderly patients

Jacob S. Young, Steven J. Chmura, Derek A. Wainwright, Bakhtiar Yamini, Katherine B. Peters, Rimas V. Lukas*

*Corresponding author for this work

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults over 55 years of age. The median age of diagnosis for patients with GBM is 64 years old, with the incidence of patients between 75 and 85 increasing. The optimal treatment paradigm for elderly GBM patients continues to evolve due to the higher frequency of age-related and/or medical co-morbidities. Geriatric GBM patients have historically been excluded from larger, controlled clinical trials due to their presumed decreased likelihood of a sustained treatment response and/or a prolonged good outcome. Here, we highlight current treatment considerations of elderly GBM patients with respect to surgical, radiotherapeutic and systemic modalities, with considerations for improving future clinical outcomes for this patient population.

Original languageEnglish (US)
Pages (from-to)250-255
Number of pages6
JournalJournal of the Neurological Sciences
Volume380
DOIs
StatePublished - Sep 15 2017

Keywords

  • Chemotherapy
  • Elderly
  • Geriatric
  • Glioblastoma
  • High-grade glioma
  • Radiation therapy
  • Surgical resection

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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