TY - JOUR
T1 - Management of hemolytic transfusion reactions in a patient with chronic myelomonocytic leukemia and rare antibodies
T2 - A case report
AU - Park, Grace S.
AU - Atluri, Himachandana
AU - DiNardo, Courtney D.
AU - Guillroy, Bryan
AU - Horak, Jean
AU - Apostolidou, Effrosyni
AU - Buni, Maryam
AU - Bravo, Guillermo Montalban
AU - Pemmaraju, Naveen
N1 - Publisher Copyright:
© 2024 The Author(s)
PY - 2025/1
Y1 - 2025/1
N2 - Delayed hemolytic transfusion reaction (DHTR) poses a significant challenge in patients receiving blood transfusions. This case report highlights the complexities of managing DHTR in a newly diagnosed chronic myelomonocytic leukemia (CMML) patient with clinically significant JKa and little c antibodies during induction chemotherapy. A 46-year-old woman with CMML-2 who presented for induction chemotherapy was found to have hemolytic anemia. Due to presence of JKa and little c antibodies, she required intensive monitoring and supportive care measures. The coexistence of JKa and little c antibodies complicates transfusion management and chemotherapy tolerance in CMML patients.
AB - Delayed hemolytic transfusion reaction (DHTR) poses a significant challenge in patients receiving blood transfusions. This case report highlights the complexities of managing DHTR in a newly diagnosed chronic myelomonocytic leukemia (CMML) patient with clinically significant JKa and little c antibodies during induction chemotherapy. A 46-year-old woman with CMML-2 who presented for induction chemotherapy was found to have hemolytic anemia. Due to presence of JKa and little c antibodies, she required intensive monitoring and supportive care measures. The coexistence of JKa and little c antibodies complicates transfusion management and chemotherapy tolerance in CMML patients.
KW - CMML
KW - Hemolytic transfusion reactions
KW - Induction therapy
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U2 - 10.1016/j.lrr.2024.100485
DO - 10.1016/j.lrr.2024.100485
M3 - Article
C2 - 39691506
AN - SCOPUS:85210356451
SN - 2213-0489
VL - 23
JO - Leukemia Research Reports
JF - Leukemia Research Reports
M1 - 100485
ER -