Management of Hormone-Sensitive Metastatic Prostate Cancer

Neeraj Agarwal, Maha Hussain*

*Corresponding author for this work

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Targeting gonadal androgen synthesis (often in conjunction with blockade of androgen receptor) is the cornerstone of treatment of hormone-sensitive metastatic prostate cancer (HSPC). Despite the failure of androgen deprivation therapy, most tumors maintain some dependence on androgen or androgen receptor signaling for proliferation. This article reviews the current standard of care for metastatic HSPC, mechanisms of treatment resistance, novel drugs targeting the androgen signaling pathway, biomarkers predicting response to treatment and survival, future directions, and ongoing clinical trials in HSPC.

Original languageEnglish (US)
Pages (from-to)1221-1241
Number of pages21
JournalHematology/Oncology Clinics of North America
Volume27
Issue number6
DOIs
StatePublished - Dec 1 2013

Keywords

  • Androgen signaling inhibitor
  • Future directions
  • Hormone-sensitive metastatic prostate cancer
  • Treatment

ASJC Scopus subject areas

  • Hematology
  • Oncology

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