Management of Immune-Related Cutaneous Adverse Reactions to PD-1 and PD-L1 Inhibitors for the Inpatient Dermatologist

Simran Chadha, Andrew J. Para, Jennifer Choi*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of Review: Programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors are immunotherapeutic agents associated with a range of auto-inflammatory cutaneous toxicities. This paper reviews the clinical approach to the diagnosis and management of immune-related cutaneous adverse events (irCAEs) to PD-1 and PD-L1 inhibitors, with emphasis on disease processes practitioners may encounter in hospitalized patients. Recent Findings: A systematic approach for suspected irCAEs has been well-detailed in recent clinical guidelines. However, the breadth of irCAE manifestations and treatment options continues to be actively delineated in the literature. Summary: The characterization and management of irCAEs is an ever-evolving realm of oncodermatology. The dermatologist’s role is to limit morbidity and mortality, maximize quality of life, and prevent discontinuation of immunotherapy. Non-steroidal immunomodulatory agents are being increasingly utilized for moderate to severe cutaneous reactions and present an opportunity for further research into safe and effective therapies.

Original languageEnglish (US)
Pages (from-to)231-243
Number of pages13
JournalCurrent Dermatology Reports
Volume9
Issue number4
DOIs
StatePublished - Dec 2020

Keywords

  • Immune checkpoint inhibitor
  • Immune-related adverse event
  • Immune-related cutaneous adverse event
  • Oncodermatology
  • PD-1 inhibitor
  • PD-L1 inhibitor

ASJC Scopus subject areas

  • Dermatology

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