Management of intussusception in children: A systematic review

Lorraine I. Kelley-Quon*, L. Grier Arthur, Regan F. Williams, Adam B. Goldin, Shawn D. St. Peter, Alana L. Beres, Yue Yung Hu, Elizabeth J. Renaud, Robert Ricca, Mark B. Slidell, Amy Taylor, Caitlin A. Smith, Doug Miniati, Juan E. Sola, Patricia Valusek, Loren Berman, Mehul V. Raval, Ankush Gosain, Matthew B. Dellinger, Stig SømmeCynthia D. Downard, Jarod P. McAteer, Akemi Kawaguchi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations


Objective: The goal of this systematic review by the American Pediatric Surgical Association Outcomes and Evidence-Based Practice Committee was to develop recommendations for the management of ileocolic intussusception in children. Methods: The, Embase, PubMed, and Scopus databases were queried for literature from January 1988 through December 2018. Search terms were designed to address the following topics in intussusception: prophylactic antibiotic use, repeated enema reductions, outpatient management, and use of minimally invasive techniques for children with intussusception. The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines were followed. Consensus recommendations were derived based on the best available evidence. Results: A total of 83 articles were analyzed and included for review. Prophylactic antibiotic use does not decrease complications after radiologic reduction. Repeated enema reductions may be attempted when clinically appropriate. Patients can be safely observed in the emergency department following enema reduction of ileocolic intussusception, avoiding hospital admission. Laparoscopic reduction is often successful. Conclusions: Regarding intussusception in hemodynamically stable children without critical illness, pre-reduction antibiotics are unnecessary, non-operative outpatient management should be maximized, and minimally invasive techniques may be used to avoid laparotomy.

Original languageEnglish (US)
Pages (from-to)587-596
Number of pages10
JournalJournal of pediatric surgery
Issue number3
StatePublished - Mar 2021


  • enema
  • intussusception
  • outpatient
  • surgery

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health


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