Management of neuroendocrine tumors of unknown origin

Ariel Polish, Maxwell T. Vergo, Mark Agulnik*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Neuroendocrine tumors (NETs) of unknown origin account for more than 10% of all NETs. Most of these tumors are poorly differentiated and, thus, very aggressive. Establishing the location of the primary tumor can be challenging. Workup of these NETs of unknown origin includes a thorough family history, immunohistochemistry, imaging, and OctreoScan. If the location of the primary malignancy is not determined, treatment is often initiated based on the grade and level of differentiation of the tumor, with well- and moderately differentiated tumors treated as carcinoid tumors, whereas poorly differentiated tumors are treated similarly to small cell tumors. Therapy is chosen based on symptoms and with the goal of debulking tumor when feasible and safe.

Original languageEnglish (US)
Pages (from-to)1397-1402
Number of pages6
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume9
Issue number12
DOIs
StatePublished - Dec 1 2011

Keywords

  • Neuroendocrine tumors
  • Unknown origin
  • Unknown primary

ASJC Scopus subject areas

  • Oncology

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