Management of nonfunctioning pituitary adenomas (NFAs): observation

Wenyu Huang, Mark E. Molitch*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


Clinically nonfunctioning pituitary adenomas (NFAs) range from those causing significant hypothalamic/pituitary dysfunction and visual field compromise due to their large size to those being completely asymptomatic. In the absence of hypersecretion, hypopituitarism or visual field defects, patients with NFAs may be followed by periodic surveillance using MRI to detect tumor enlargement. In some cases, endocrine tests are also needed during observation to discover new pituitary dysfunction. Enlargement of NFAs without treatment occurs in about 10% of microadenomas and 23% of macroadenomas. Growth of a pituitary incidentaloma, the development of visual field defects or the development of hypopituitarism are potential indications for surgery during follow up.

Original languageEnglish (US)
Pages (from-to)162-167
Number of pages6
Issue number2
StatePublished - Apr 1 2018


  • Adenoma
  • Incidentaloma
  • Nonfunctioning
  • Observation
  • Pituitary
  • Tumor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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