TY - JOUR
T1 - Management of prolactinomas
AU - Molitch, M. E.
PY - 1989
Y1 - 1989
N2 - Prolactinomas are the most common of the hormone-secreting pituitary tumors and must be distinguished from nonsecreting tumors causing hyperprolactinemia by hypothalamic or stalk dysfunction. For both micro- and macroadenomas, dopamine agonists appear to be the treatment of choice, transsphenoidal surgery being reserved for nonresponders. For women desiring pregnancy, dopamine agonists are safe when there is a microadenoma or an intrasellar macroadenoma. However, in women with large macroadenomas desiring pregnancy, limited transsphenoidal decompression followed by bromocriptine appears to be the safest mode of treatment.
AB - Prolactinomas are the most common of the hormone-secreting pituitary tumors and must be distinguished from nonsecreting tumors causing hyperprolactinemia by hypothalamic or stalk dysfunction. For both micro- and macroadenomas, dopamine agonists appear to be the treatment of choice, transsphenoidal surgery being reserved for nonresponders. For women desiring pregnancy, dopamine agonists are safe when there is a microadenoma or an intrasellar macroadenoma. However, in women with large macroadenomas desiring pregnancy, limited transsphenoidal decompression followed by bromocriptine appears to be the safest mode of treatment.
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U2 - 10.1146/annurev.me.40.020189.001301
DO - 10.1146/annurev.me.40.020189.001301
M3 - Review article
C2 - 2658749
AN - SCOPUS:0024379274
SN - 0066-4219
VL - 40
SP - 225
EP - 232
JO - Annual Review of Medicine
JF - Annual Review of Medicine
ER -