Management strategies and future challenges for aortic valve disease

Robert O. Bonow*, Martin B. Leon, Darshan Doshi, Neil Moat

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations


The management of aortic valve disease has been improved by accurate diagnosis and assessment of severity by echocardiography and advanced imaging techniques, efforts to elicit symptoms or objective markers of disease severity and progression, and consideration of optimum timing of aortic valve replacement, even in elderly patients. Prevalence of calcific aortic stenosis is growing in ageing populations. Conventional surgery remains the most appropriate option for most patients who require aortic valve replacement, but the transcatheter approach is established for high-risk patients or poor candidates for surgery. The rapid growth of transcatheter aortic valve replacement has been fuelled by improved technology, evidence-based clinical research, and setting up of multidisciplinary heart teams. Aortic regurgitation can be difficult to diagnose and quantify. Left ventricular dysfunction often precedes symptoms, needing active surveillance by echocardiography to determine the optimum time for aortic valve replacement. Development of transcatheter approaches for aortic regurgitation is challenging, owing to the absence of valvular calcification and distortion of aortic root anatomy in many patients.

Original languageEnglish (US)
Pages (from-to)1312-1323
Number of pages12
JournalThe Lancet
Issue number10025
StatePublished - Mar 26 2016

ASJC Scopus subject areas

  • General Medicine


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