Managing Disease and Therapy-Related Complications in Patients with Central Nervous System Tumors

Jeffrey J. Raizer*, Karan S. Dixit

*Corresponding author for this work

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Treating patients with brain tumors can be divided into tumor-directed therapies, the management of tumor-related symptoms and complications and the psychosocial aspect of patient care. In this review, we will discuss the management of disease and treatment-related complications, which can negatively impact patient quality of life and functional status. Brain edema is a common complication or brain tumors and often causes more symptoms than the tumor itself. Treatment options are limited to the use of corticosteroids, which although effective have a plethora of side effects, so the goal should be the lowest dose that maximizes symptoms. Seizures are more common in lower grade brain tumors and treatment should be limited to patients who have seizures using agents that do not affect the metabolism of other drugs, especially chemotherapies. Blood clots are also common in patients and although there is a “fear” of tumoral bleeding, this is not a frequent occurrence; hence, using anticoagulants should be routinely used in patients who experience this complication.

Original languageEnglish (US)
Article number38
JournalCurrent treatment options in oncology
Volume16
Issue number8
DOIs
StatePublished - Aug 3 2015

Fingerprint

Central Nervous System Neoplasms
Brain Neoplasms
Seizures
Therapeutics
Neoplasms
Brain Edema
Disease Management
Anticoagulants
Fear
Patient Care
Adrenal Cortex Hormones
Thrombosis
Quality of Life
Hemorrhage
Drug Therapy
Pharmaceutical Preparations

Keywords

  • Anticoagulation
  • Antiepileptic drugs
  • Brain tumors
  • Corticosteroids
  • Edema
  • Pneumocystis jiroveci
  • Seizures
  • Steroid myopathy
  • Venous thromboembolism
  • Venous thromboembolism

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

Cite this

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abstract = "Treating patients with brain tumors can be divided into tumor-directed therapies, the management of tumor-related symptoms and complications and the psychosocial aspect of patient care. In this review, we will discuss the management of disease and treatment-related complications, which can negatively impact patient quality of life and functional status. Brain edema is a common complication or brain tumors and often causes more symptoms than the tumor itself. Treatment options are limited to the use of corticosteroids, which although effective have a plethora of side effects, so the goal should be the lowest dose that maximizes symptoms. Seizures are more common in lower grade brain tumors and treatment should be limited to patients who have seizures using agents that do not affect the metabolism of other drugs, especially chemotherapies. Blood clots are also common in patients and although there is a “fear” of tumoral bleeding, this is not a frequent occurrence; hence, using anticoagulants should be routinely used in patients who experience this complication.",
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Managing Disease and Therapy-Related Complications in Patients with Central Nervous System Tumors. / Raizer, Jeffrey J.; Dixit, Karan S.

In: Current treatment options in oncology, Vol. 16, No. 8, 38, 03.08.2015.

Research output: Contribution to journalReview article

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AB - Treating patients with brain tumors can be divided into tumor-directed therapies, the management of tumor-related symptoms and complications and the psychosocial aspect of patient care. In this review, we will discuss the management of disease and treatment-related complications, which can negatively impact patient quality of life and functional status. Brain edema is a common complication or brain tumors and often causes more symptoms than the tumor itself. Treatment options are limited to the use of corticosteroids, which although effective have a plethora of side effects, so the goal should be the lowest dose that maximizes symptoms. Seizures are more common in lower grade brain tumors and treatment should be limited to patients who have seizures using agents that do not affect the metabolism of other drugs, especially chemotherapies. Blood clots are also common in patients and although there is a “fear” of tumoral bleeding, this is not a frequent occurrence; hence, using anticoagulants should be routinely used in patients who experience this complication.

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