Managment of hypothalamic gliomas in children: An analysis of 33 cases

L. A. Rodriguez, M. S B Edwards, V. A. Levin, T. Tomita

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

The cases of 33 children with hypothalamic-chiasmatic gliomas are reviewed. Radiation therapy produced clinical or radiographic improvement in 11 (46%) of 24 patients. Progression was documented in 18 patients (54%). Overall, the median time to tumor progression was 60 months; it was 70 months in patients who received radiation therapy and 30 months in those who did not (P < 0.05). Chemotherapy, either given initially or at the time of progression, caused the tumor to respond or to stabilize in 10 patients. Partial resection of the tumor led to improvement in 3 of 12 patients, obviating the need for a shunt in 2 of them; there were no deaths and postoperative morbidity was transient and minimal (diabetes insipidus, intraventricular hemorrhage, and left hemiparesis in one patient each). The 5- and 10-year survival probabilities were 93 and 74%, respectively. Patients with neurofibromatosis had a better prognosis.

Original languageEnglish (US)
Pages (from-to)242-247
Number of pages6
JournalNeurosurgery
Volume26
Issue number2
DOIs
StatePublished - 1990

Keywords

  • chemotherapy
  • chiasmatic-hypothalamic glioma
  • neurofibromatosis
  • radiation therapy

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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