Manipulating replication processes within a dynamic covalent framework

Vicente Del Amo*, Alexandra M.Z. Slawin, Douglas Philp

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


(Chemical Equation Presented) The reaction of an amine bearing an amidopyridine recognition site and an aldehyde bearing a carboxylic acid recognition site affords an imine that is capable of directing its own formation through a dynamic covalent replication cycle. Additionally, the amine, formed by reduction of the replicating imine, is a more efficient catalyst for the formation of the replicating imine than the imine is a catalyst for its own formation.

Original languageEnglish (US)
Pages (from-to)4589-4592
Number of pages4
JournalOrganic Letters
Issue number20
StatePublished - 2008

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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