Manipulation of Neuronal Ion Channels

Research output: Patent

Abstract

Manipulation of Neuronal Ion Channels as a Treatment for Parkinson's Disease NU 2002-110 Inventors Gytis Baranauskas Dalton James Surmeier* Tatiana Tkatch Short Description Identification of methods to decrease pathophysiological high frequency neuronal bursts of Parkinson's and related diseases. Abstract Northwestern researchers developed compositions and methods to manipulate ion channels to decrease pathophysiological high frequency neuronal bursts of Parkinson's and related diseases. This invention focuses on the targeted disruption of potassium channels in the globus pallidus and subthalamic nucleus. By directing a toxin specifically against the KV3.4a subunits, the fast-spiking neuronal cells lose its ability to discharge at a high rate. Applications Research tool for neurological diseases Therapy for Parkinson's disease Advantages Minimized disrupted normal neuronal functioning Minimized side effects Publications Baranauskas G, Tkatch T, Nagata K, Yeh JZ, Surmeier DJ (2003) Kv3.4 subunits enhance the repolarizing efficiency of Kv3.1 channels in fast-spiking neurons. Nature Neuroscience. 6: 258-66. IP Status Issued US Patent No. 7,629,323 Marketing Contact Michael Moore, PhD Invention Manager (p) (847) 491-4645 (e) michaelmoore@northwestern.edu
Original languageEnglish
Patent number7629323
StatePublished - Dec 8 2009

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