TY - PAT
T1 - Manipulation of Neuronal Ion Channels
AU - Surmeier Jr, Dalton James
N1 - filingdate: 2004-1-21
issueddate: 2009-12-8
Status: published
attorneydocketnumber: 2002-110-03
PY - 2009/12/8
Y1 - 2009/12/8
N2 - Manipulation of Neuronal Ion Channels as a Treatment for Parkinson's Disease
NU 2002-110
Inventors
Gytis Baranauskas
Dalton James Surmeier*
Tatiana Tkatch
Short Description
Identification of methods to decrease pathophysiological high frequency neuronal bursts of Parkinson's and related diseases.
Abstract
Northwestern researchers developed compositions and methods to manipulate ion channels to decrease pathophysiological high frequency neuronal bursts of Parkinson's and related diseases. This invention focuses on the targeted disruption of potassium channels in the globus pallidus and subthalamic nucleus. By directing a toxin specifically against the KV3.4a subunits, the fast-spiking neuronal cells lose its ability to discharge at a high rate.
Applications
Research tool for neurological diseases
Therapy for Parkinson's disease
Advantages
Minimized disrupted normal neuronal functioning
Minimized side effects
Publications
Baranauskas G, Tkatch T, Nagata K, Yeh JZ, Surmeier DJ (2003) Kv3.4 subunits enhance the repolarizing efficiency of Kv3.1 channels in fast-spiking neurons. Nature Neuroscience. 6: 258-66.
IP Status
Issued US Patent No. 7,629,323
Marketing Contact
Michael Moore, PhD
Invention Manager
(p) (847) 491-4645
(e) michaelmoore@northwestern.edu
AB - Manipulation of Neuronal Ion Channels as a Treatment for Parkinson's Disease
NU 2002-110
Inventors
Gytis Baranauskas
Dalton James Surmeier*
Tatiana Tkatch
Short Description
Identification of methods to decrease pathophysiological high frequency neuronal bursts of Parkinson's and related diseases.
Abstract
Northwestern researchers developed compositions and methods to manipulate ion channels to decrease pathophysiological high frequency neuronal bursts of Parkinson's and related diseases. This invention focuses on the targeted disruption of potassium channels in the globus pallidus and subthalamic nucleus. By directing a toxin specifically against the KV3.4a subunits, the fast-spiking neuronal cells lose its ability to discharge at a high rate.
Applications
Research tool for neurological diseases
Therapy for Parkinson's disease
Advantages
Minimized disrupted normal neuronal functioning
Minimized side effects
Publications
Baranauskas G, Tkatch T, Nagata K, Yeh JZ, Surmeier DJ (2003) Kv3.4 subunits enhance the repolarizing efficiency of Kv3.1 channels in fast-spiking neurons. Nature Neuroscience. 6: 258-66.
IP Status
Issued US Patent No. 7,629,323
Marketing Contact
Michael Moore, PhD
Invention Manager
(p) (847) 491-4645
(e) michaelmoore@northwestern.edu
M3 - Patent
M1 - 7629323
ER -