Manipulation of the innate immune response by human papillomaviruses

Shiyuan Hong, Laimonis A. Laimins*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

The innate immune response constitutes the first line of defense against infections by pathogens. Successful pathogens such as human papillomaviruses (HPVs) have evolved mechanisms that target several points in these pathways including sensing of viral genomes, blocking the synthesis of interferons and inhibiting the action of JAK/STAT transcription factors. Disruption of these inhibitory mechanisms contributes to the ability of HPVs to establish persistent infections, which is the major etiological factor in the development of anogenital cancers. Interestingly, HPVs also positively activate several members of these pathways such as STAT-5 that are important for their differentiation-dependent life cycle. STAT-5 activation induces the ATM and ATR DNA damage response pathways that play critical roles in HPV genome amplification. Targeting of these pathways by pharmaceuticals can provide novel opportunities to inhibit infections by these important human pathogens.

Original languageEnglish (US)
Pages (from-to)34-40
Number of pages7
JournalVirus Research
Volume231
DOIs
StatePublished - Mar 2 2017

Keywords

  • Inflammasome
  • Interferons
  • JAK-STAT pathway
  • PAMPs

ASJC Scopus subject areas

  • Cancer Research
  • Virology
  • Infectious Diseases

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