Mannitol bolus preferentially shrinks non-infarcted brain in patients with ischemic stroke

Tom O. Videen*, A. R. Zazulia, E. M. Manno, C. P. Derdeyn, R. E. Adams, M. N. Diringer, W. J. Powers

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

Changes in brain tissue volume in six patients who had acute complete middle cerebral artery (MCA) infarctions and CT evidence of midline shift were measured using the brain boundary shift integral (BBSI) on sequential T1-weighted MR images acquired before and after a 1.5-g/kg bolus infusion of mannitol. At 50 to 55 minutes after the baseline scan, total brain volume decreased by 8.1 ± 2.8 mL (0.6%, p < 0.005). Brain in the noninfarcted hemisphere shrank more (0.8 ± 0.4%) than in the infarcted hemisphere (0.0 ± 0.5%, p < 0.05).

Original languageEnglish (US)
Pages (from-to)2120-2122
Number of pages3
JournalNeurology
Volume57
Issue number11
DOIs
StatePublished - Dec 11 2001

ASJC Scopus subject areas

  • Clinical Neurology

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