Many substrates and functions of type II secretion: Lessons learned from Legionella pneumophila

Nicholas P. Cianciotto*

*Corresponding author for this work

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Type II secretion is one of six systems that exist in Gram-negative bacteria for the purpose of secreting proteins into the extracellular milieu and/or into host cells. This article will review the various recent studies of Legionella pneumophila that have increased our appreciation of the numbers, types and novelties of proteins that can be secreted via the type II system, as well as the many ways in which type II secretion can promote bacterial physiology, growth, ecology, intracellular infection and virulence. In this context, type II secretion represents a potentially important target for industrial and biomedical applications.

Original languageEnglish (US)
Pages (from-to)797-805
Number of pages9
JournalFuture Microbiology
Volume4
Issue number7
DOIs
StatePublished - 2009

Keywords

  • Gram-negative bacteria
  • Intracellular infection
  • Legionella pneumophila
  • Legionnaires' disease
  • Secreted enzyme
  • Sliding motility
  • Type II secretion
  • Virulence

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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