Mapping acute lesion locations to physiological swallow impairments after stroke

Janina Wilmskoetter; Leonardo Bonilha; Bonnie Martin-Harris; Jordan J. Elm; Janet Horn; Heather S. Bonilha

doi:10.1016/j.nicl.2019.101685

Mapping acute lesion locations to physiological swallow impairments after stroke

Janina Wilmskoetter^*, Leonardo Bonilha, Bonnie Martin-Harris, Jordan J. Elm, Janet Horn, Heather S. Bonilha

^*Corresponding author for this work

Communication Sciences and Disorders

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Dysphagia is a common deficit after a stroke, and it is frequently associated with pneumonia, malnutrition, dehydration, and poor quality of life. It is not yet fully clear which brain regions are directly related to swallowing, and how lesions affect swallow physiology. This study aimed to assess the statistical relationship between acute stroke lesion locations and impairment of specific aspects of swallow physiology. We performed lesion symptom mapping with 68 retrospectively recruited, acute, first-ever ischemic stroke patients. Lesions were determined on diffusion weighted MRI scans.

Original language	English (US)
Article number	101685
Journal	NeuroImage: Clinical
Volume	22
DOIs	https://doi.org/10.1016/j.nicl.2019.101685
State	Published - Jan 1 2019

Funding

Janina Wilmskoetter receives salary from the Medical University of South Carolina. Leonardo Bonilha reports no disclosures. Bonnie Martin-Harris is funded by NIH / NIDCD grants # 1K24DC12801 and # 1R01DC011290 , receives research support from Bracco Diagnostics, and holds copyright royalties from Northern Speech Services and the Medical University of South Carolina. Jordan J. Elm reports no disclosures. Janet Horn receives a stipend/salary from the Medical University of South Carolina. Heather S. Bonilha is funded by NIH / NIDDK grant # R01 DK098222 , by the Center for Biomedical Research Excellence (COBRE) in Stroke Recovery at the Medical University of South Carolina (MUSC) in Charleston, South Carolina, #5P20GM109040, serves as an editorial board member for ASHA journal, serves as a grant reviewer for NIH, and receives salary from the Medical University of South Carolina. The project described was supported in part by the National Institutes of Health / National Center for Advancing Translational Sciences (NCATS) through Grant Number UL1 TR001450 , SCTR Pilot Project 17254, Center for Biomedical Research Excellence (COBRE) in Stroke Recovery at the Medical University of South Carolina (MUSC) in Charleston, South Carolina through Grant Number 5P20GM109040 , and National Institutes of Health / National Institute on Deafness and Other Communication Disorders (NIDCD) through Grant Number T32DC014435 .

Keywords

Deglutition
Deglutition disorders
Lesion analysis
Magnetic resonance imaging
Stroke

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Neurology
Clinical Neurology
Cognitive Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.nicl.2019.101685

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title = "Mapping acute lesion locations to physiological swallow impairments after stroke",

abstract = "Dysphagia is a common deficit after a stroke, and it is frequently associated with pneumonia, malnutrition, dehydration, and poor quality of life. It is not yet fully clear which brain regions are directly related to swallowing, and how lesions affect swallow physiology. This study aimed to assess the statistical relationship between acute stroke lesion locations and impairment of specific aspects of swallow physiology. We performed lesion symptom mapping with 68 retrospectively recruited, acute, first-ever ischemic stroke patients. Lesions were determined on diffusion weighted MRI scans.",

keywords = "Deglutition, Deglutition disorders, Lesion analysis, Magnetic resonance imaging, Stroke",

author = "Janina Wilmskoetter and Leonardo Bonilha and Bonnie Martin-Harris and Elm, {Jordan J.} and Janet Horn and Bonilha, {Heather S.}",

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AU - Bonilha, Leonardo

AU - Martin-Harris, Bonnie

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AU - Horn, Janet

AU - Bonilha, Heather S.

PY - 2019/1/1

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N2 - Dysphagia is a common deficit after a stroke, and it is frequently associated with pneumonia, malnutrition, dehydration, and poor quality of life. It is not yet fully clear which brain regions are directly related to swallowing, and how lesions affect swallow physiology. This study aimed to assess the statistical relationship between acute stroke lesion locations and impairment of specific aspects of swallow physiology. We performed lesion symptom mapping with 68 retrospectively recruited, acute, first-ever ischemic stroke patients. Lesions were determined on diffusion weighted MRI scans.

AB - Dysphagia is a common deficit after a stroke, and it is frequently associated with pneumonia, malnutrition, dehydration, and poor quality of life. It is not yet fully clear which brain regions are directly related to swallowing, and how lesions affect swallow physiology. This study aimed to assess the statistical relationship between acute stroke lesion locations and impairment of specific aspects of swallow physiology. We performed lesion symptom mapping with 68 retrospectively recruited, acute, first-ever ischemic stroke patients. Lesions were determined on diffusion weighted MRI scans.

KW - Deglutition

KW - Deglutition disorders

KW - Lesion analysis

KW - Magnetic resonance imaging

KW - Stroke

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ER -

Mapping acute lesion locations to physiological swallow impairments after stroke

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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