Abstract
Objective: The structural and functional organization of brain networks subserving basic daily activities (i.e. language, visuo-spatial cognition, movement, semantics, etc.) are not completely understood to date. Here, we report the first probabilistic cortical and subcortical atlas of critical structures mediating human brain functions based on direct electrical stimulation (DES), a well-validated tool for the exploration of cerebral processing and for performing safe surgical interventions in eloquent areas. Methods: We collected 1162 cortical and 659 subcortical DES responses during testing of 16 functional domains in 256 patients undergoing awake surgery. Spatial coordinates for each functional response were calculated, and probability distributions for the entire patient cohort were mapped onto a standardized three-dimensional brain template using a multinomial statistical analysis. In addition, matching analyses were performed against prior established anatomy-based cortical and white matter (WM) atlases. Results: The probabilistic maps for each functional domain were provided. The topographical analysis demonstrated a wide spatial distribution of cortical functional responses, while subcortical responses were more restricted, localizing to known WM pathways. These DES-derived data showed reliable matching with existing cortical and WM atlases as well as recent neuroimaging and neurophysiological data. Conclusions: We present the first integrated and comprehensive cortical-subcortical atlas of structures essential for humans’ neural functions based on highly-specific DES mapping during real-time neuropsychological testing. This novel atlas can serve as a complementary tool for neuroscientists, along with data obtained from other modalities, to improve and refine our understanding of the functional anatomy of critical brain networks.
| Original language | English (US) |
|---|---|
| Article number | 116237 |
| Journal | Neuroimage |
| Volume | 205 |
| DOIs | |
| State | Published - Jan 15 2020 |
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Keywords
- Atlas
- Brain functions
- Brain mapping
- Direct electrical stimulation
- Subcortical
- White matter
ASJC Scopus subject areas
- Neurology
- Cognitive Neuroscience
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Mapping critical cortical hubs and white matter pathways by direct electrical stimulation : an original functional atlas of the human brain. / Sarubbo, Silvio; Tate, Matthew; De Benedictis, Alessandro; Merler, Stefano; Moritz-Gasser, Sylvie; Herbet, Guillaume; Duffau, Hugues.
In: Neuroimage, Vol. 205, 116237, 15.01.2020.Research output: Contribution to journal › Article
TY - JOUR
T1 - Mapping critical cortical hubs and white matter pathways by direct electrical stimulation
T2 - an original functional atlas of the human brain
AU - Sarubbo, Silvio
AU - Tate, Matthew
AU - De Benedictis, Alessandro
AU - Merler, Stefano
AU - Moritz-Gasser, Sylvie
AU - Herbet, Guillaume
AU - Duffau, Hugues
PY - 2020/1/15
Y1 - 2020/1/15
N2 - Objective: The structural and functional organization of brain networks subserving basic daily activities (i.e. language, visuo-spatial cognition, movement, semantics, etc.) are not completely understood to date. Here, we report the first probabilistic cortical and subcortical atlas of critical structures mediating human brain functions based on direct electrical stimulation (DES), a well-validated tool for the exploration of cerebral processing and for performing safe surgical interventions in eloquent areas. Methods: We collected 1162 cortical and 659 subcortical DES responses during testing of 16 functional domains in 256 patients undergoing awake surgery. Spatial coordinates for each functional response were calculated, and probability distributions for the entire patient cohort were mapped onto a standardized three-dimensional brain template using a multinomial statistical analysis. In addition, matching analyses were performed against prior established anatomy-based cortical and white matter (WM) atlases. Results: The probabilistic maps for each functional domain were provided. The topographical analysis demonstrated a wide spatial distribution of cortical functional responses, while subcortical responses were more restricted, localizing to known WM pathways. These DES-derived data showed reliable matching with existing cortical and WM atlases as well as recent neuroimaging and neurophysiological data. Conclusions: We present the first integrated and comprehensive cortical-subcortical atlas of structures essential for humans’ neural functions based on highly-specific DES mapping during real-time neuropsychological testing. This novel atlas can serve as a complementary tool for neuroscientists, along with data obtained from other modalities, to improve and refine our understanding of the functional anatomy of critical brain networks.
AB - Objective: The structural and functional organization of brain networks subserving basic daily activities (i.e. language, visuo-spatial cognition, movement, semantics, etc.) are not completely understood to date. Here, we report the first probabilistic cortical and subcortical atlas of critical structures mediating human brain functions based on direct electrical stimulation (DES), a well-validated tool for the exploration of cerebral processing and for performing safe surgical interventions in eloquent areas. Methods: We collected 1162 cortical and 659 subcortical DES responses during testing of 16 functional domains in 256 patients undergoing awake surgery. Spatial coordinates for each functional response were calculated, and probability distributions for the entire patient cohort were mapped onto a standardized three-dimensional brain template using a multinomial statistical analysis. In addition, matching analyses were performed against prior established anatomy-based cortical and white matter (WM) atlases. Results: The probabilistic maps for each functional domain were provided. The topographical analysis demonstrated a wide spatial distribution of cortical functional responses, while subcortical responses were more restricted, localizing to known WM pathways. These DES-derived data showed reliable matching with existing cortical and WM atlases as well as recent neuroimaging and neurophysiological data. Conclusions: We present the first integrated and comprehensive cortical-subcortical atlas of structures essential for humans’ neural functions based on highly-specific DES mapping during real-time neuropsychological testing. This novel atlas can serve as a complementary tool for neuroscientists, along with data obtained from other modalities, to improve and refine our understanding of the functional anatomy of critical brain networks.
KW - Atlas
KW - Brain functions
KW - Brain mapping
KW - Direct electrical stimulation
KW - Subcortical
KW - White matter
UR - http://www.scopus.com/inward/record.url?scp=85073760247&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073760247&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2019.116237
DO - 10.1016/j.neuroimage.2019.116237
M3 - Article
C2 - 31626897
AN - SCOPUS:85073760247
VL - 205
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
M1 - 116237
ER -