Mapping of Class I and Class II Odorant Receptors to Glomerular Domains by Two Distinct Types of Olfactory Sensory Neurons in the Mouse

Thomas Bozza*, Anne Vassalli, Stefan Fuss, Jing Ji Zhang, Brian Weiland, Rodrigo Pacifico, Paul Feinstein, Peter Mombaerts

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

123 Scopus citations

Abstract

The repertoire of ∼1200 odorant receptors (ORs) is mapped onto the array of ∼1800 glomeruli in the mouse olfactory bulb (OB). The spatial organization of this array is influenced by the ORs. Here we show that glomerular mapping to broad domains in the dorsal OB is determined by two types of olfactory sensory neurons (OSNs), which reside in the dorsal olfactory epithelium. The OSN types express either class I or class II OR genes. Axons from the two OSN types segregate already within the olfactory nerve and form distinct domains of glomeruli in the OB. These class-specific anatomical domains correlate with known functional odorant response domains. However, axonal segregation and domain formation are not determined by the class of the expressed OR protein. Thus, the two OSN types are determinants of axonal wiring, operate at a higher level than ORs, and contribute to the functional organization of the glomerular array.

Original languageEnglish (US)
Pages (from-to)220-233
Number of pages14
JournalNeuron
Volume61
Issue number2
DOIs
StatePublished - Jan 29 2009

Keywords

  • CELLBIO
  • DEVBIO
  • MOLNEURO

ASJC Scopus subject areas

  • Neuroscience(all)

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