Mapping of the binding site for Mannheimia haemolytica leukotoxin within bovine CD18

T. Dileepan, M. S. Kannan, B. Walcheck, P. Thumbikat, S. K. Maheswaran*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

To map the site involved in Mannheimia haemolytica leukotoxin (LktA) binding and biological activity within bovine CD18, bovine × human CD18 chimeric constructs were generated and coexpressed with bovine CD11a in K562 cells. Studies with the chimeric leukocyte function-associated antigen 1 transductants demonstrate that the site required for LktA binding and biological effects resides within amino acid residues 500 and 600 of the extracellular region of bovine CD18.

Original languageEnglish (US)
Pages (from-to)5233-5237
Number of pages5
JournalInfection and immunity
Volume73
Issue number8
DOIs
StatePublished - Aug 2005

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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