Marked relationship between matrix metalloproteinase 7 and brain atrophy in HIV infection

Ann B. Ragin*, Ying Wu, Renee Ochs, Hongyan Du, Leon G. Epstein, Katherine Conant, Justin C. McArthur

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Circulating levels of matrix metalloproteinases (MMP-1 and 7) have been found to correlate with the severity of brain injury in HIV-infected subjects. This study used high-resolution neuroanatomic imaging and automated segmentation algorithms to clarify this relationship. Both metalloproteinases were significantly correlated with increased cerebrospinal fluid volume fraction. Comprehensive brain volumetric analysis revealed a more marked relationship with atrophy for MMP-7, which was significantly correlated with neural injury in multiple brain regions and nearly all ventricular measurements. MMP-7 was also correlated with measures of virologic and cognitive status.

Original languageEnglish (US)
Pages (from-to)153-158
Number of pages6
JournalJournal of neurovirology
Volume17
Issue number2
DOIs
StatePublished - Apr 2011

Keywords

  • HIV-dementia
  • MMP-1
  • MMP-7
  • NeuroAIDS
  • Quantitative MRI

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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