MarR family proteins are important regulators of clinically relevant antibiotic resistance

Grace A. Beggs, Richard G. Brennan, Mehreen Arshad*

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

There has been a rapid spread of multidrug-resistant (MDR) bacteria across the world. MDR efflux transporters are an important mechanism of antibiotic resistance in many pathogens among both Gram positive and Gram negative bacteria. These pumps can recognize a variety of chemically and structurally different compounds, including innate and clinically administered antibiotics. Intriguingly, these efflux pumps are often regulated by transcription factors that themselves bind a diverse set of substrates thereby allowing them to regulate the expression of their cognate MDR efflux pumps. One significant family of such transcription factors is the Multiple antibiotic resistance Repressor (MarR) family. Members of this family are well conserved across different bacterial species and in some cases are known to regulate vital bacterial functions. This review focusses on the role of MarR family transcriptional factors in antibiotic resistance within a select group of clinically relevant pathogens.

Original languageEnglish (US)
Pages (from-to)647-653
Number of pages7
JournalProtein Science
Volume29
Issue number3
DOIs
Publication statusPublished - Mar 1 2020

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Keywords

  • MarR
  • antibiotic
  • pathogens
  • resistance

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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