Maspin and cathepsin d partnership in regulating mammary gland development and breast cancer

Zhila Khalkhali-Ellis*, Ming Zhang, Mary J C Hendrix

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Maspin (mammary serine protease inhibitor) was identified in 1994by subtractive hybridization analysis of normal mammary tissue andbreast cancer cell lines. Although Maspin exhibited sequence homologywith members of the serine protease inhibitor superfamily, based on itsstructure and in the absence of an identified protease ligand, Maspin wasconsidered a non-inhibitory serpin. Maspin is expressed in myoepithelial,epithelial and adipocyte components of mammary tissue, and plays acritical role in mammary gland development. After a decade of intensiveresearch, Maspin is now recognized as a multifaceted protein, interactingwith a diverse group of intra- and extra-cellular proteins, regulating amultitude of cellular functions.Our laboratory has identified the aspartyl lysosomal proteinasecathepsin D (CatD) as a putative Maspin binding partner. Apart from itswell studied function in intercellular clearance of proteins, CatD iscritically involved in apoptotic cell death. In addition, excessiveproduction and aberrant secretion of CatD are believed to contribute tobreast cancer progression and metastasis. To date, our studies haveilluminated novel aspects of the CatD and Maspin partnership inregulating key stages of normal mammary gland differentiation andremodeling. In this short communication we will examine this complexinteraction, and speculate on how alteration in pathways operative inmammary gland remodeling could promote malignant growth.

Original languageEnglish (US)
Title of host publicationBreast Cancer
Subtitle of host publicationCauses, Diagnosis and Treatment
EditorsMR Romero
PublisherNova Science Publishers, Inc.
Pages161-176
Number of pages16
ISBN (Print)9781608764631
StatePublished - Dec 1 2011

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Fingerprint Dive into the research topics of 'Maspin and cathepsin d partnership in regulating mammary gland development and breast cancer'. Together they form a unique fingerprint.

  • Cite this

    Khalkhali-Ellis, Z., Zhang, M., & Hendrix, M. J. C. (2011). Maspin and cathepsin d partnership in regulating mammary gland development and breast cancer. In MR. Romero (Ed.), Breast Cancer: Causes, Diagnosis and Treatment (pp. 161-176). Nova Science Publishers, Inc..