Massive ethylene glycol poisoning without evidence of crystalluria

A case for early intervention

Michael C. Haupt, David N Zull, Stephen L Adams*

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A case of severe ethylene glycol poisoning is presented, characterized by protracted delirium, coma, and delayed adult respiratory distress syndrome. This patient never demonstrated evidence of calcium oxalate crystalluria or renal insufficiency. Ethylene glycol intoxication should be considered in the patient who presents with an altered mental status, unexplained metabolic acidosis, and elevated anion and osmolal gaps with or without crystalluria. Early empiric ethanol therapy and consideration of dialysis are recommended for those patients with such a presentation without evidence of abnormal levels of ketones, lactate, solicylate, or ethanol. It is proposed that early ethanol therapy may prevent the formation of ethylene glycol metabolites to the extent that calcium oxalate crystalluria is not seen.

Original languageEnglish (US)
Pages (from-to)295-300
Number of pages6
JournalJournal of Emergency Medicine
Volume6
Issue number4
DOIs
StatePublished - Jan 1 1988

Fingerprint

Ethylene Glycol
Poisoning
Calcium Oxalate
Ethanol
Acid-Base Equilibrium
Delirium
Adult Respiratory Distress Syndrome
Coma
Secondary Prevention
Acidosis
Ketones
Renal Insufficiency
Dialysis
Lactic Acid
Therapeutics

Keywords

  • anion gap
  • elevated anion gap metabolic acidosis
  • ethylene glycol poisoning without crystalluria
  • metabolic acidosis

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

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abstract = "A case of severe ethylene glycol poisoning is presented, characterized by protracted delirium, coma, and delayed adult respiratory distress syndrome. This patient never demonstrated evidence of calcium oxalate crystalluria or renal insufficiency. Ethylene glycol intoxication should be considered in the patient who presents with an altered mental status, unexplained metabolic acidosis, and elevated anion and osmolal gaps with or without crystalluria. Early empiric ethanol therapy and consideration of dialysis are recommended for those patients with such a presentation without evidence of abnormal levels of ketones, lactate, solicylate, or ethanol. It is proposed that early ethanol therapy may prevent the formation of ethylene glycol metabolites to the extent that calcium oxalate crystalluria is not seen.",
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Massive ethylene glycol poisoning without evidence of crystalluria : A case for early intervention. / Haupt, Michael C.; Zull, David N; Adams, Stephen L.

In: Journal of Emergency Medicine, Vol. 6, No. 4, 01.01.1988, p. 295-300.

Research output: Contribution to journalArticle

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