Mast Cell Interactions and Crosstalk in Regulating Allergic Inflammation

Tania E. Velez, Paul J. Bryce, Kathryn E Hulse*

*Corresponding author for this work

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Purpose of Review: This review summarizes recent findings on mast cell biology with a focus on IgE-independent roles of mast cells in regulating allergic responses. Recent Findings: Recent studies have described novel mast cell-derived molecules, both secreted and membrane-bound, that facilitate cross-talk with a variety of immune effector cells to mediate type 2 inflammatory responses. Summary: Mast cells are complex and dynamic cells that are persistent in allergy and are capable of providing signals that lead to the initiation and persistence of allergic mechanisms.

Original languageEnglish (US)
Article number30
JournalCurrent allergy and asthma reports
Volume18
Issue number5
DOIs
StatePublished - May 1 2018

Fingerprint

Mast Cells
Cell Communication
Inflammation
Immunoglobulin E
Cell Biology
Hypersensitivity
Membranes

Keywords

  • Allergy
  • B cells
  • Histamine
  • IgE
  • Mast cells
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

Cite this

@article{cd6b05422f4f4955834533947b72b65b,
title = "Mast Cell Interactions and Crosstalk in Regulating Allergic Inflammation",
abstract = "Purpose of Review: This review summarizes recent findings on mast cell biology with a focus on IgE-independent roles of mast cells in regulating allergic responses. Recent Findings: Recent studies have described novel mast cell-derived molecules, both secreted and membrane-bound, that facilitate cross-talk with a variety of immune effector cells to mediate type 2 inflammatory responses. Summary: Mast cells are complex and dynamic cells that are persistent in allergy and are capable of providing signals that lead to the initiation and persistence of allergic mechanisms.",
keywords = "Allergy, B cells, Histamine, IgE, Mast cells, T cells",
author = "Velez, {Tania E.} and Bryce, {Paul J.} and Hulse, {Kathryn E}",
year = "2018",
month = "5",
day = "1",
doi = "10.1007/s11882-018-0786-6",
language = "English (US)",
volume = "18",
journal = "Current Allergy and Asthma Reports",
issn = "1529-7322",
publisher = "Current Medicine Group",
number = "5",

}

Mast Cell Interactions and Crosstalk in Regulating Allergic Inflammation. / Velez, Tania E.; Bryce, Paul J.; Hulse, Kathryn E.

In: Current allergy and asthma reports, Vol. 18, No. 5, 30, 01.05.2018.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Mast Cell Interactions and Crosstalk in Regulating Allergic Inflammation

AU - Velez, Tania E.

AU - Bryce, Paul J.

AU - Hulse, Kathryn E

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Purpose of Review: This review summarizes recent findings on mast cell biology with a focus on IgE-independent roles of mast cells in regulating allergic responses. Recent Findings: Recent studies have described novel mast cell-derived molecules, both secreted and membrane-bound, that facilitate cross-talk with a variety of immune effector cells to mediate type 2 inflammatory responses. Summary: Mast cells are complex and dynamic cells that are persistent in allergy and are capable of providing signals that lead to the initiation and persistence of allergic mechanisms.

AB - Purpose of Review: This review summarizes recent findings on mast cell biology with a focus on IgE-independent roles of mast cells in regulating allergic responses. Recent Findings: Recent studies have described novel mast cell-derived molecules, both secreted and membrane-bound, that facilitate cross-talk with a variety of immune effector cells to mediate type 2 inflammatory responses. Summary: Mast cells are complex and dynamic cells that are persistent in allergy and are capable of providing signals that lead to the initiation and persistence of allergic mechanisms.

KW - Allergy

KW - B cells

KW - Histamine

KW - IgE

KW - Mast cells

KW - T cells

UR - http://www.scopus.com/inward/record.url?scp=85045640697&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045640697&partnerID=8YFLogxK

U2 - 10.1007/s11882-018-0786-6

DO - 10.1007/s11882-018-0786-6

M3 - Review article

VL - 18

JO - Current Allergy and Asthma Reports

JF - Current Allergy and Asthma Reports

SN - 1529-7322

IS - 5

M1 - 30

ER -