Mast cells and the adaptive immune response

Melissa Ann Brown, Blayne A. Sayed, Alison Christy

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Background: The idea that the innate and adaptive immune systems are not separate entities is no longer new. In fact, it is surprising that this paradigm was accepted without question for so long. Many innate cells express cell surface molecules and soluble mediators that are essential for the development and activation of T cells and B cells. Yet among the innate cell populations, mast cells may play the major role in regulating adaptive immune cell function. Discussion: This role first came to light in studies of mast cells and their involvement in the autoimmune disease experimental allergic encephalomyelitis, the major rodent model of multiple sclerosis and has subsequently been verified in many in vitro and in vivo model systems.

Original languageEnglish (US)
Pages (from-to)671-676
Number of pages6
JournalJournal of Clinical Immunology
Volume28
Issue number6
DOIs
StatePublished - Nov 1 2008

Keywords

  • Autoimmunity
  • MS/EAE
  • Mast cells and adaptive immunity
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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