Mast cells in allergy and autoimmunity: implications for adaptive immunity.

Gregory D. Gregory*, Melissa A. Brown

*Corresponding author for this work

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

As in the fashion industry, trends in a particular area of scientific investigation often are fleeting but then return with renewed and enthusiastic interest. Studies of mast cell biology are good examples of this. Although dogma once relegated mast cells almost exclusively to roles in pathological inflammation associated with allergic disease, these cells are emerging as important players in a number of other physiological processes. Consequently, they are quickly becoming the newest "trendy" cell, both within and outside the field of immunology. As sources of a large array of pro- and anti-inflammatory mediators, mast cells also express cell surface molecules with defined functions in lymphocyte activation and trafficking. Here, we provide an overview of the traditional and newly appreciated contributions of mast cells to both innate and adaptive immune responses.

Original languageEnglish (US)
Pages (from-to)35-50
Number of pages16
JournalMethods in molecular biology (Clifton, N.J.)
Volume315
StatePublished - Jan 1 2006

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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