Matching nucleotide sequences of human antibodies with other known sequences

Tai Te Wu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

From an evolutionary point of view, the complementarity-determining regions of antibodies are distinct from other proteins including the framework regions of antibodies. A search for identical nucleotide sequences of eighty-four 15 consecutive bp in the complementarity-determining regions of human antibody heavy chains with other known sequences yielded four matches: two sequential 15-bp matches, or one 16-bp match, with the coding region of a sea-urchin testis histone H2b-2, one 15-bp match with the promotor region of a cauliflower mosaic virus inclusion body protein, and a 15-bp match with an intron between exons 1 and 2 of human factor IX. As a control, an identical search of eighty-four 15 consecutive bp in the framework regions of human antibody heavy chains yielded no matches with other sequences except those from other antibody framwork regions. Since the currently available nucleotide sequence database used in the search consisted of about 1 × 107 bp, finding such matches in the complementarity-determining regions might not be random.

Original languageEnglish (US)
Pages (from-to)231-234
Number of pages4
JournalJournal of Theoretical Biology
Volume131
Issue number2
DOIs
StatePublished - Mar 21 1988

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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