Materials and Design Approaches for a Fully Bioresorbable, Electrically Conductive and Mechanically Compliant Cardiac Patch Technology

Hanjun Ryu, Xinlong Wang*, Zhaoqian Xie, Jihye Kim, Yugang Liu, Wubin Bai, Zhen Song, Joseph W. Song, Zichen Zhao, Joohee Kim, Quansan Yang, Janice Jie Xie, Rebecca Keate, Huifeng Wang, Yonggang Huang, Igor R. Efimov, Guillermo Antonio Ameer*, John A. Rogers*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Myocardial infarction (MI) is one of the leading causes of death and disability. Recently developed cardiac patches provide mechanical support and additional conductive paths to promote electrical signal propagation in the MI area to synchronize cardiac excitation and contraction. Cardiac patches based on conductive polymers offer attractive features; however, the modest levels of elasticity and high impedance interfaces limit their mechanical and electrical performance. These structures also operate as permanent implants, even in cases where their utility is limited to the healing period of tissue damaged by the MI. The work presented here introduces a highly conductive cardiac patch that combines bioresorbable metals and polymers together in a hybrid material structure configured in a thin serpentine geometry that yields elastic mechanical properties. Finite element analysis guides optimized choices of layouts in these systems. Regular and synchronous contraction of human induced pluripotent stem cell-derived cardiomyocytes on the cardiac patch and ex vivo studies offer insights into the essential properties and the bio-interface. These results provide additional options in the design of cardiac patches to treat MI and other cardiac disorders.

Original languageEnglish (US)
Article number2303429
JournalAdvanced Science
Issue number27
StatePublished - Sep 26 2023


  • bioresorbable materials
  • cardiac patch
  • heterogeneous integration
  • myocardial infraction

ASJC Scopus subject areas

  • General Engineering
  • General Chemical Engineering
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • General Materials Science
  • General Physics and Astronomy
  • Medicine (miscellaneous)


Dive into the research topics of 'Materials and Design Approaches for a Fully Bioresorbable, Electrically Conductive and Mechanically Compliant Cardiac Patch Technology'. Together they form a unique fingerprint.

Cite this