Materials and Design Approaches for a Fully Bioresorbable, Electrically Conductive and Mechanically Compliant Cardiac Patch Technology

Hanjun Ryu; Xinlong Wang; Zhaoqian Xie; Jihye Kim; Yugang Liu; Wubin Bai; Zhen Song; Joseph W. Song; Zichen Zhao; Joohee Kim; Quansan Yang; Janice Jie Xie; Rebecca Keate; Huifeng Wang; Yonggang Huang; Igor R. Efimov; Guillermo Antonio Ameer; John A. Rogers

doi:10.1002/advs.202303429

Materials and Design Approaches for a Fully Bioresorbable, Electrically Conductive and Mechanically Compliant Cardiac Patch Technology

Hanjun Ryu, Xinlong Wang^*, Zhaoqian Xie, Jihye Kim, Yugang Liu, Wubin Bai, Zhen Song, Joseph W. Song, Zichen Zhao, Joohee Kim, Quansan Yang, Janice Jie Xie, Rebecca Keate, Huifeng Wang, Yonggang Huang, Igor R. Efimov, Guillermo Antonio Ameer^*, John A. Rogers^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Myocardial infarction (MI) is one of the leading causes of death and disability. Recently developed cardiac patches provide mechanical support and additional conductive paths to promote electrical signal propagation in the MI area to synchronize cardiac excitation and contraction. Cardiac patches based on conductive polymers offer attractive features; however, the modest levels of elasticity and high impedance interfaces limit their mechanical and electrical performance. These structures also operate as permanent implants, even in cases where their utility is limited to the healing period of tissue damaged by the MI. The work presented here introduces a highly conductive cardiac patch that combines bioresorbable metals and polymers together in a hybrid material structure configured in a thin serpentine geometry that yields elastic mechanical properties. Finite element analysis guides optimized choices of layouts in these systems. Regular and synchronous contraction of human induced pluripotent stem cell-derived cardiomyocytes on the cardiac patch and ex vivo studies offer insights into the essential properties and the bio-interface. These results provide additional options in the design of cardiac patches to treat MI and other cardiac disorders.

Original language	English (US)
Article number	2303429
Journal	Advanced Science
Volume	10
Issue number	27
DOIs	https://doi.org/10.1002/advs.202303429
State	Published - Sep 26 2023

Funding

H.R., X.W., Z.X., and J.K. contributed equally to this work. This work made use of the NUFAB facility of Northwestern University's NUANCE Center, which had received support from the SHyNE Resource (NSF ECCS‐2025633), the IIN, and Northwestern's MRSEC program (NSF DMR‐1720139), and the Northwestern University RHLCCC Flow Cytometry Facility and a Cancer Center Support Grant (NCI CA060553). H.R. acknowledged support from the Technology Innovation Program (20025736, Development of MICS SoC and platform for in vivo implantable electroceutical device) funded By the Ministry of Trade, Industry & Energy (MOTIE, Korea) and the National Research Foundation of Korea(NRF) grant funded by the Korea government (MSIT) (No. RS‐2023‐00244336). X.W. acknowledged support from the American Heart Association (AHA 19POST34400088). Z.X. acknowledged the support from the National Natural Science Foundation of China (grant No. 12072057), Dalian Outstanding Young Talents in Science and Technology (grant No. 2021RJ06), LiaoNing Revitalization Talents Program (Grant No. XLYC2007196), and International Cooperation Fund Project of DBJI (grant no. ICR2110). Y.H. acknowledged support from NSF (grant No. CMMI1635443). The Center for Advanced Regenerative Engineering provided partial funding support for this study. H.R., X.W., Z.X., and J.K. contributed equally to this work. This work made use of the NUFAB facility of Northwestern University's NUANCE Center, which had received support from the SHyNE Resource (NSF ECCS-2025633), the IIN, and Northwestern's MRSEC program (NSF DMR-1720139), and the Northwestern University RHLCCC Flow Cytometry Facility and a Cancer Center Support Grant (NCI CA060553). H.R. acknowledged support from the Technology Innovation Program (20025736, Development of MICS SoC and platform for in vivo implantable electroceutical device) funded By the Ministry of Trade, Industry & Energy (MOTIE, Korea) and the National Research Foundation of Korea(NRF) grant funded by the Korea government (MSIT) (No. RS-2023-00244336). X.W. acknowledged support from the American Heart Association (AHA 19POST34400088). Z.X. acknowledged the support from the National Natural Science Foundation of China (grant No. 12072057), Dalian Outstanding Young Talents in Science and Technology (grant No. 2021RJ06), LiaoNing Revitalization Talents Program (Grant No. XLYC2007196), and International Cooperation Fund Project of DBJI (grant no. ICR2110). Y.H. acknowledged support from NSF (grant No. CMMI1635443). The Center for Advanced Regenerative Engineering provided partial funding support for this study.

Keywords

bioresorbable materials
cardiac patch
heterogeneous integration
myocardial infraction

ASJC Scopus subject areas

Medicine (miscellaneous)
General Chemical Engineering
General Materials Science
Biochemistry, Genetics and Molecular Biology (miscellaneous)
General Engineering
General Physics and Astronomy

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10.1002/advs.202303429

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Ryu, H., Wang, X., Xie, Z., Kim, J., Liu, Y., Bai, W., Song, Z., Song, J. W., Zhao, Z., Kim, J., Yang, Q., Xie, J. J., Keate, R., Wang, H., Huang, Y., Efimov, I. R., Ameer, G. A., & Rogers, J. A. (2023). Materials and Design Approaches for a Fully Bioresorbable, Electrically Conductive and Mechanically Compliant Cardiac Patch Technology. Advanced Science, 10(27), Article 2303429. https://doi.org/10.1002/advs.202303429

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abstract = "Myocardial infarction (MI) is one of the leading causes of death and disability. Recently developed cardiac patches provide mechanical support and additional conductive paths to promote electrical signal propagation in the MI area to synchronize cardiac excitation and contraction. Cardiac patches based on conductive polymers offer attractive features; however, the modest levels of elasticity and high impedance interfaces limit their mechanical and electrical performance. These structures also operate as permanent implants, even in cases where their utility is limited to the healing period of tissue damaged by the MI. The work presented here introduces a highly conductive cardiac patch that combines bioresorbable metals and polymers together in a hybrid material structure configured in a thin serpentine geometry that yields elastic mechanical properties. Finite element analysis guides optimized choices of layouts in these systems. Regular and synchronous contraction of human induced pluripotent stem cell-derived cardiomyocytes on the cardiac patch and ex vivo studies offer insights into the essential properties and the bio-interface. These results provide additional options in the design of cardiac patches to treat MI and other cardiac disorders.",

keywords = "bioresorbable materials, cardiac patch, heterogeneous integration, myocardial infraction",

author = "Hanjun Ryu and Xinlong Wang and Zhaoqian Xie and Jihye Kim and Yugang Liu and Wubin Bai and Zhen Song and Song, {Joseph W.} and Zichen Zhao and Joohee Kim and Quansan Yang and Xie, {Janice Jie} and Rebecca Keate and Huifeng Wang and Yonggang Huang and Efimov, {Igor R.} and Ameer, {Guillermo Antonio} and Rogers, {John A.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.",

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Ryu, H, Wang, X, Xie, Z, Kim, J, Liu, Y, Bai, W, Song, Z, Song, JW, Zhao, Z, Kim, J, Yang, Q, Xie, JJ, Keate, R, Wang, H, Huang, Y , Efimov, IR , Ameer, GA & Rogers, JA 2023, 'Materials and Design Approaches for a Fully Bioresorbable, Electrically Conductive and Mechanically Compliant Cardiac Patch Technology', Advanced Science, vol. 10, no. 27, 2303429. https://doi.org/10.1002/advs.202303429

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T1 - Materials and Design Approaches for a Fully Bioresorbable, Electrically Conductive and Mechanically Compliant Cardiac Patch Technology

AU - Ryu, Hanjun

AU - Wang, Xinlong

AU - Xie, Zhaoqian

AU - Kim, Jihye

AU - Liu, Yugang

AU - Bai, Wubin

AU - Song, Zhen

AU - Song, Joseph W.

AU - Zhao, Zichen

AU - Kim, Joohee

AU - Yang, Quansan

AU - Xie, Janice Jie

AU - Keate, Rebecca

AU - Wang, Huifeng

AU - Huang, Yonggang

AU - Efimov, Igor R.

AU - Ameer, Guillermo Antonio

AU - Rogers, John A.

PY - 2023/9/26

Y1 - 2023/9/26

N2 - Myocardial infarction (MI) is one of the leading causes of death and disability. Recently developed cardiac patches provide mechanical support and additional conductive paths to promote electrical signal propagation in the MI area to synchronize cardiac excitation and contraction. Cardiac patches based on conductive polymers offer attractive features; however, the modest levels of elasticity and high impedance interfaces limit their mechanical and electrical performance. These structures also operate as permanent implants, even in cases where their utility is limited to the healing period of tissue damaged by the MI. The work presented here introduces a highly conductive cardiac patch that combines bioresorbable metals and polymers together in a hybrid material structure configured in a thin serpentine geometry that yields elastic mechanical properties. Finite element analysis guides optimized choices of layouts in these systems. Regular and synchronous contraction of human induced pluripotent stem cell-derived cardiomyocytes on the cardiac patch and ex vivo studies offer insights into the essential properties and the bio-interface. These results provide additional options in the design of cardiac patches to treat MI and other cardiac disorders.

AB - Myocardial infarction (MI) is one of the leading causes of death and disability. Recently developed cardiac patches provide mechanical support and additional conductive paths to promote electrical signal propagation in the MI area to synchronize cardiac excitation and contraction. Cardiac patches based on conductive polymers offer attractive features; however, the modest levels of elasticity and high impedance interfaces limit their mechanical and electrical performance. These structures also operate as permanent implants, even in cases where their utility is limited to the healing period of tissue damaged by the MI. The work presented here introduces a highly conductive cardiac patch that combines bioresorbable metals and polymers together in a hybrid material structure configured in a thin serpentine geometry that yields elastic mechanical properties. Finite element analysis guides optimized choices of layouts in these systems. Regular and synchronous contraction of human induced pluripotent stem cell-derived cardiomyocytes on the cardiac patch and ex vivo studies offer insights into the essential properties and the bio-interface. These results provide additional options in the design of cardiac patches to treat MI and other cardiac disorders.

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Materials and Design Approaches for a Fully Bioresorbable, Electrically Conductive and Mechanically Compliant Cardiac Patch Technology

Abstract

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